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Titolo:
Populations and genetic polymorphisms
Autore:
Weber, WW;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA
Titolo Testata:
MOLECULAR DIAGNOSIS
fascicolo: 4, volume: 4, anno: 1999,
pagine: 299 - 307
SICI:
1084-8592(199912)4:4<299:PAGP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZERS; MOLECULAR-BIOLOGY; CYP2D6 GENE; DEBRISOQUINE; ALLELE; HYDROXYLATION; PHENOTYPE; SPARTEINE; NOMENCLATURE; DEFICIENT;
Keywords:
ethnic specificity; pharmacogenetics; human drug response; human evolution; genetic polymorphism; racial variation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, WW Univ Michigan, Dept Pharmacol, 1301B-MSRB 3, Ann Arbor, MI 48109USA Univ Michigan 1301B-MSRB 3 Ann Arbor MI USA 48109 , MI 48109 USA
Citazione:
W.W. Weber, "Populations and genetic polymorphisms", MOL DIAGN, 4(4), 1999, pp. 299-307

Abstract

Background: Population frequencies of many polymorphic genes of pharmacogenetic interest depend on race or ethnic specificity. Association of these genes with person-to-person differences in drug effectiveness (hypersensitivity or resistance) and drug toxicity may also depend on the racial or ethnic characteristics of a population. Information about ethnic specificity is an integral part of pharmacogenetics because it can suggest a starting point for further study of these traits, tailoring drug therapy to the individual patient, and rational development and clinical trials of new drugs. Ethnic specificities of several medically important metabolic traits serve to illustrate these ideas. Among the traits considered is primaquine sensitivity, a sex-linked trait attributed to glucose-6-phosphate dehydrogenase deficiency that mainly affects males among African, Mediterranean, and Oriental people. Additional examples include the remarkable sensitivity of the Japanese to alcohol (ethanol) compared with whites; the ethnic specificity of the cytochrome P-450 enzyme CYP2D6* (debrisoquine/sparteine) polymorphism that results in poor, extensive, and ultrarapid metabolizers of at least 30 drugs; the CYP2C19* (mephenytoin) polymorphism that accounts for variable metabolism of proguanil, omeprazole, and certain barbiturates; and the polymorphic (NAT2*) acetylation of hydrazine and aromatic amine drugs, such as isoniazid, hydralazine, and sulfasalazine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:57:37