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Titolo:
Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats
Autore:
Gupta, S; Rajvanshi, P; Irani, AN; Palestro, CJ; Bhargava, KK;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx,NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx,NY 10461 USA Dept Med, Div Gastroenterol, Bronx, NY USA Dept Med Bronx NY USADept Med, Div Gastroenterol, Bronx, NY USA Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Radiol, Div Nucl Med, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Nucl Med, Bronx, NY 10467 USA
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 190, anno: 2000,
pagine: 203 - 210
SICI:
0022-3417(200002)190:2<203:IAPOTC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LIVER-FAILURE; MICROCARRIER-ATTACHED HEPATOCYTES; HEPATOCELLULAR TRANSPLANTATION; GENE-THERAPY; IN-VIVO; MODEL; REPOPULATION; DEFICIENT; REPLACEMENT; INJECTION;
Keywords:
acute liver failure; animal; hepatocyte; toxic; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, S Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Ullmann 625,1300 Morris Pk Ave, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Ullmann 625,1300 Morris Pk Ave Bronx NY USA 10461
Citazione:
S. Gupta et al., "Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats", J PATHOLOGY, 190(2), 2000, pp. 203-210

Abstract

To determine whether liver repopulation with cell transplantation could beof therapeutic value in acute hepatic failure, it is necessary to establish the fate of transplanted hepatocytes, This study used dipeptidyl peptidase IV-deficient F344 rats as recipients to analyse the engraftment and proliferation of transplanted hepatocytes, Syngeneic hepatocytes were transplanted intrasplenically 24-30 h after induction of liver injury by D-galactosamine (GalN), Portosystemic shunting was analysed with 99m-Tc-labelled albumin microspheres, GalN-treated rats showed characteristic hepatic necrosis, inflammation, gamma-glutamyl transpeptidase activation, and regenerative activity, without increased portosystemic shunting (>99% 99m-Tc activity was in the liver in normal and GalN-treated rats). Transplanted cells entered hepatic sinusoids promptly and were observed in liver plates at 48 h, The number of transplanted cells increased in GalN-treated rats by approximately seven-fold (range two- to 12-fold), along with evidence for DNA synthesis between 3 and 14 days after cell transplantation and greater prevalence of larger transplanted cell clusters. These findings indicate that the liver canbe safely repopulated in animals with acute liver failure, although the time required for regenesis of plasma membrane structures and proliferation in transplanted hepatocytes will need to be considered in developing therapeutic strategies. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:35:06