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Titolo:
Chemical stimulation of the ventral hippocampus elevates nucleus accumbensdopamine by activating dopaminergic neurons of the ventral tegmental area
Autore:
Legault, M; Rompre, PP; Wise, RA;
Indirizzi:
Univ Montreal, Ctr Rech Fernand Seguin, Montreal, PQ H1N 3V2, Canada Univ Montreal Montreal PQ Canada H1N 3V2 in, Montreal, PQ H1N 3V2, Canada Univ Montreal, Dept Psychiat, Montreal, PQ H1N 3V2, Canada Univ Montreal Montreal PQ Canada H1N 3V2 at, Montreal, PQ H1N 3V2, Canada Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 20, anno: 2000,
pagine: 1635 - 1642
SICI:
0270-6474(20000215)20:4<1635:CSOTVH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; INVIVO PRESYNAPTIC CONTROL; CAT CAUDATE-NUCLEUS; ELECTRICAL-STIMULATION; IN-VIVO; RAT; RELEASE; GLUTAMATE; SUBICULUM; LOCOMOTOR;
Keywords:
ventral subiculum; microdialysis; tetrodotoxin; single unit; NMDA; ventral tegmental area; accumbens; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Legault, M Univ Montreal, Ctr Rech Fernand Seguin, 7331 Rue Hochelaga, Montreal, PQ H1N 3V2, Canada Univ Montreal 7331 Rue Hochelaga Montreal PQ Canada H1N 3V2 ada
Citazione:
M. Legault et al., "Chemical stimulation of the ventral hippocampus elevates nucleus accumbensdopamine by activating dopaminergic neurons of the ventral tegmental area", J NEUROSC, 20(4), 2000, pp. 1635-1642

Abstract

Dual-probe microdialysis (with HPLC and electrochemical detection) in freely moving rats and single-unit recording in anesthetized rats were used to study the extent to which impulse flow through the ventral tegmental area (VTA) contributes to elevations in nucleus accumbens (NAS) dopamine (DA) evoked by stimulation of the ventral subiculum (VS). During perfusion of artificial extracellular fluid into the VTA, injections of 0.74 mg of the excitatory amino acid NMDA into the VS elevated accumbens DA to >150% of basal values. During intra-VTA perfusion of either 1 mu M tetrodotoxin (which blocks impulse flow) or 1 mM kynurenic acid (which blocks excitatory glutamate receptors), injections of NMDA into the VS failed to elevate accumbens DA. Thus, increased impulse flow through VTA DA neurons, mediated by excitatory glutamate inputs to this region, appears critical for VS stimulation to elevate NAS DA. Increased impulse flow through VTA DA neurons was confirmed using single-unit recording in anesthetized rats. Intra-VS NMDA injections increased the firing rates of 45% (14 of 31), decreased the firing rates of 13% (4 of 31), and had no effect on 42% (13 of 31) of VTA DA neurons. Increases in firing rates were evident within 15 min of NMDA injections, a time at which VS NMDA injections elevate accumbens DA in awake animals. The results of the present experiments identify the VTA as a critical site through which outputs from the VS modulate NAS dopaminergic neurotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:43:42