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Titolo:
Thalamic-evoked synaptic interactions in barrel cortex revealed by opticalimaging
Autore:
Laaris, N; Carlson, GC; Keller, A;
Indirizzi:
Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 & Neurobiol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 am Neurosci, Baltimore, MD 21201 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 20, anno: 2000,
pagine: 1529 - 1537
SICI:
0270-6474(20000215)20:4<1529:TSIIBC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOCORTICAL PYRAMIDAL NEURONS; PRIMARY SOMATOSENSORY CORTEX; RECEPTIVE-FIELD PROPERTIES; CENTRAL NERVOUS-SYSTEM; NON-NMDA RECEPTORS; EPILEPTIFORM DISCHARGES; FUNCTIONAL-ORGANIZATION; POSTSYNAPTIC POTENTIALS; LAMINAR DIFFERENCES; AXON COLLATERALS;
Keywords:
somatosensory cortex; voltage-sensitive dyes; glutamate; NMDA; GABA; epilepsy; temporal coding; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Keller, A Univ Maryland, Sch Med, Dept Anat & Neurobiol, 685 W Baltimore St, Baltimore, MD 21201 USA Univ Maryland 685 W Baltimore St Baltimore MD USA 21201 1201 USA
Citazione:
N. Laaris et al., "Thalamic-evoked synaptic interactions in barrel cortex revealed by opticalimaging", J NEUROSC, 20(4), 2000, pp. 1529-1537

Abstract

We used optical imaging of voltage-sensitive dye signals to study the spatiotemporal spread of activity in the mouse barrel cortex, evoked by stimulation of thalamocortical afferents in an in vitro slice preparation. Stimulation of the thalamus, at low current intensity, results in activity largelyrestricted to a single barrel, and to the border between layers Vb and VI. Low concentrations of the GABAA receptor antagonist bicuculline increase the amplitude of the optical signals, without affecting their spatiotemporalpropagation. Higher concentrations of bicuculline result in paroxysmal activity, which propagates via intracolumnar and intercolumnar excitatory pathways. Enhancing the activity of NMDA receptors, by removing Mg2+ from the extracellular solution, dramatically alters the spatiotemporal pattern of excitation: activity spreads to supragranular and infragranular layers and adjacent barrel columns. This enhanced propagation is suppressed by the NMDA receptor antagonist AP5. A similar enhancement of activity propagation can be produced by stimulating the thalamus with a short, high-frequency pulse train. Application of AP5 suppresses the frequency-dependent spread of activity. These findings indicate that the spatiotemporal spread of activity inthe barrel cortex is altered by varying the temporal patterns of thalamic inputs, via an NMDA receptor-mediated mechanism, and suggest that a similarprocess occurs during repetitive whisking activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 22:06:46