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Titolo:
Discharge properties of juxtacellularly labeled and immunohistochemically identified cholinergic basal forebrain neurons recorded in association withthe electroencephalogram in anesthetized rats
Autore:
Manns, ID; Alonso, A; Jones, BE;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 20, anno: 2000,
pagine: 1505 - 1518
SICI:
0270-6474(20000215)20:4<1505:DPOJLA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; LAYER-II NEURONS; NUCLEUS BASALIS; THETA-RHYTHM; ENTORHINAL CORTEX; CEREBRAL-CORTEX; NEOCORTICAL ACTIVATION; ELECTRICAL-ACTIVITY; POPULATION ACTIVITY; CORTICAL ACTIVITY;
Keywords:
acetylcholine; bursting; choline acetyl transferase; cortical activation; slow rhythmic activity; theta; sleepwake states;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, BE McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQCanada H3A 2B4 2B4, Canada
Citazione:
I.D. Manns et al., "Discharge properties of juxtacellularly labeled and immunohistochemically identified cholinergic basal forebrain neurons recorded in association withthe electroencephalogram in anesthetized rats", J NEUROSC, 20(4), 2000, pp. 1505-1518

Abstract

Multiple lines of evidence indicate that cholinergic basal forebrain neurons play an important role in the regulation of cortical activity and state. However, the discharge properties of cholinergic cells in relation to the electroencephalogram (EEG) are not yet known. In the present study, cells were recorded in the basal forebrain in association with cortical EEG activity in urethane-anesthetized rats, and their discharge was examined during EEG irregular slow activity and during stimulation-induced cortical activation, characterized by rhythmic slow (theta) and high-frequency (gamma) activities. Recorded cells were labeled with Neurobiotin (Nb), using the juxtacellular technique and identified as cholinergic by immunohistochemical staining for choline acetyltransferase (ChAT). Nb-positive/ChAT-positive neuronswere distinctive and significantly different from Nb-positive/ChAT-negative neurons, which were heterogeneous in their discharge properties. All Nb1/ChAT1 cells increased their discharge rate with stimulation, and most shifted from an irregular tonic discharge during EEG slow irregular activity to a rhythmic burst discharge during rhythmic slow activity. The stimulation-induced rhythmic discharge was cross-correlated with the EEG rhythmic slow activity. In some units the rhythmic discharge matched the rhythmic slow activity of the retrosplenial cortex; in others, it matched that of the prefrontal cortex, which occurred at a slower frequency, suggesting that subsets of cholinergic neurons may influence their cortical target areas rhythmically at particular frequencies. Cholinergic basal forebrain neurons thus may evoke and enhance cortical activation via both an increase in rate and a change in pattern to rhythmic bursting that would stimulate rhythmic slow (theta-like) activity in cortical fields during active waking and paradoxical sleep states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:32:54