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Titolo:
Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice
Autore:
Santucci, L; Fiorucci, S; Cammilleri, F; Servillo, G; Federici, B; Morelli, A;
Indirizzi:
Univ Perugia, Clin Gastroenterol & Epatol, I-06122 Perugia, Italy Univ Perugia Perugia Italy I-06122 erol & Epatol, I-06122 Perugia, Italy Univ Perugia, Ist Patol Gen, Dipartimento Med Clin & Sperimentale, I-06122Perugia, Italy Univ Perugia Perugia Italy I-06122 & Sperimentale, I-06122Perugia, Italy
Titolo Testata:
HEPATOLOGY
fascicolo: 2, volume: 31, anno: 2000,
pagine: 399 - 406
SICI:
0270-9139(200002)31:2<399:GEIAPE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; THYMIC EPITHELIAL-CELLS; DEPENDENT LIVER-INJURY; INTERFERON-GAMMA; T-CELLS; ENDOGENOUS LECTIN; FAS LIGAND; IFN-GAMMA; APOPTOSIS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Santucci, L Univ Perugia, Clin Gastroenterol & Epatol, I-06122 Perugia, Italy Univ Perugia Perugia Italy I-06122 l, I-06122 Perugia, Italy
Citazione:
L. Santucci et al., "Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice", HEPATOLOGY, 31(2), 2000, pp. 399-406

Abstract

Galectin-1, an endogenous lectin with immunomodulatory activities, inducesselective, Fas-independent apoptosis of activated T cells. The aim of the present study was to evaluate the effect galectin-1 exerts on concanavalin A (Con A)-induced hepatitis, a T-cell-dependent model of liver injury. Con A administration resulted in liver injury, as shown by the increased transaminase plasma levels and liver DNA fragmentation, and caused spleen T-cell activation, which was associated with a strong increment in liver infiltrating T helper cells. Moreover, Con A injection leads to a marked increase inplasma tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) levels. Galectin-1 pretreatment dose-dependently prevented both liverinjury and T-helper cell liver infiltration induced by Con A. In vivo and in vitro experiments indicated that the protective effects of galectin-1 depend on the selective elimination of Con A-activated T cells. In addition, galectin-1 almost completely prevented the Con A-induced increase in plasmaTNF-alpha and IFN-gamma, an effect that was, at least in part, independenton the elimination of activated T helper cells, because galectin-1 prevented lipopolysaccharide (LPS)induced release of TNF-alpha and IFN-gamma also from macrophages in vitro, without affecting their viability. The present study suggests that galectin-1 is potentially useful in the treatment of T-cell-mediated human liver disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:51:44