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Titolo:
Autonomic dysfunction is related to impaired pancreatic beta cell functionin patients with coronary artery disease
Autore:
Sayer, JW; Marchant, B; Gelding, SV; Cooper, JA; Timmis, AD;
Indirizzi:
London Chest Hosp, Royal Hosp NHS Trust, Dept Cardiol, London E2 9JX, England London Chest Hosp London England E2 9JX Cardiol, London E2 9JX, England Newham Gen Hosp, Dept Endocrinol & Diabet, London E13, England Newham Gen Hosp London England E13 ocrinol & Diabet, London E13, England
Titolo Testata:
HEART
fascicolo: 2, volume: 83, anno: 2000,
pagine: 210 - 216
SICI:
1355-6037(200002)83:2<210:ADIRTI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; HEART-RATE-VARIABILITY; CARDIOVASCULAR RISK-FACTORS; FREQUENCY-DOMAIN MEASURES; DIABETES-MELLITUS; CIRCADIAN VARIATION; INSULIN-RESISTANCE; SPECTRAL-ANALYSIS; NONDIABETIC SUBJECTS; PERIOD VARIABILITY;
Keywords:
ischaemic heart disease; autonomic nervous system; beta cell function; diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Timmis, AD London Chest Hosp, Royal Hosp NHS Trust, Dept Cardiol, Bonner Rd, London E2 9JX, England London Chest Hosp Bonner Rd London England E2 9JX 9JX, England
Citazione:
J.W. Sayer et al., "Autonomic dysfunction is related to impaired pancreatic beta cell functionin patients with coronary artery disease", HEART, 83(2), 2000, pp. 210-216

Abstract

Objective-To assess the role of beta cell failure in the development of autonomic dysfunction in patients with coronary artery disease. Design-Autonomic function was measured by standard clinical methods and byheart rate variability in 24 type II diabetic and 24 non-diabetic subjectswith coronary artery disease. Quantitative estimates of pancreatic beta cell function (%beta) and insulin resistance were made from basal plasma glucose and insulin concentrations using a computer solved model. Fasting proinsulin levels provided an independent measure of beta cell function. Results-The circadian rhythm of sympathovagal balance (ratio of low to high frequency spectral components of heart rate variability) was significantly attenuated in patients with below median (%beta less than or equal to 63.3) compared with above median pancreatic beta cell function. Multiple measures of autonomic function showed positive associations with %beta (low frequency: r = 0.41, p = 0.004; high frequency: r = 0.27, p = 0.07; lying/standing fall in systolic pressure: r = -0.30, p = 0.04) and negative associations with proinsulin (low frequency: r = -0.35, p = 0.03; high frequency: r =-0.36, p = 0.02; standard deviation of RR intervals: r = -0.43, p = 0.007). Associations tended to be stronger in non-diabetic than diabetic patients. In contrast, there was no association between insulin resistance and either autonomic function or the circadian rhythm of sympathovagal balance, regardless of diabetes status. Conclusions-The data are consistent with the hypothesis that beta cell failure plays a pathogenic role in the development of autonomic dysfunction inpatients with coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:50:52