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Titolo:
Preferred treatment of infertile women older than 37 years of age who demonstrate premature luteinization in the first evaluation cycle
Autore:
Lidor, AL; Cohen, SB; Seidman, DS; Mashiach, S; Lipitz, S; Goldenberg, M;
Indirizzi:
Chaim Sheba Med Ctr, Dept Obstet & Gynecol, Reprod Med Unit, IL-52621 Tel Hashomer, Ramat Gan, Israel Chaim Sheba Med Ctr Tel Hashomer Ramat Gan Israel IL-52621 at Gan, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 2, volume: 73, anno: 2000,
pagine: 321 - 324
SICI:
0015-0282(200002)73:2<321:PTOIWO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; SERUM PROGESTERONE LEVELS; HUMAN MENOPAUSAL GONADOTROPIN; HORMONE-RELEASING HORMONE; INVITRO FERTILIZATION; LEUPROLIDE ACETATE; EMBRYO TRANSFER; OVARIAN HYPERSTIMULATION; MEIOTIC MATURATION; AGONIST;
Keywords:
premature luteinization; ovulation induction; infertility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Lidor, AL Chaim Sheba Med Ctr, Dept Obstet & Gynecol, Reprod Med Unit, IL-52621 Tel Hashomer, Ramat Gan, Israel Chaim Sheba Med Ctr Tel Hashomer Ramat Gan Israel IL-52621 rael
Citazione:
A.L. Lidor et al., "Preferred treatment of infertile women older than 37 years of age who demonstrate premature luteinization in the first evaluation cycle", FERT STERIL, 73(2), 2000, pp. 321-324

Abstract

Objective: To evaluate the efficacy of various treatments in abolishing premature luteinization in infertile women over 37 years old who are undergoing ovulation induction. Design: Prospective, nonrandomized study. Setting: Tertiary care medical clinic. Patient(s): Seventeen infertile women >37 years old in whom premature luteinization was detected during their evaluation (pretreatment) cycle. Intervention(s): The patients underwent three consecutive treatment cycleswith clomiphene citrate (group A), hMG (group B), and a GnRH agonist plus hMG (group C). Main Outcome Measure(s): Premature luteinization, defined as a progesterone/E-2 ratio of >1 on the day of hCG administration. Result(s): Fifteen (88%) of the 17 patients in group A and 13 (76%) of the17 patients in group B demonstrated premature luteinization. In contrast, only 1 (6%) of the 17 patients in group C had a progesterone/E-2 ratio of >1 on the day of hCG administration. The mean (+/-SD) E-2 level on the day of hCG administration was significantly higher in group C (1,236 +/- 772.7 pg/mL) than in group A (214.02 +/- 104.46 pg/mL) or group B (412.5 +/- 337 pg/mL). Conclusion(s): Pituitary desensitization with a GnRH agonist in conjunction with hMG may be of benefit for older infertile women who demonstrate early luteinization in their first evaluation cycle. (Fertil Steril(R) 2000; 73:321-4. (C)2000 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:37