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Titolo:
The periodontal pathogen Porphyromonas gingivalis harnesses the chemistry of the mu-oxo bishaem of iron protoporphyrin IX to protect against hydrogenperoxide
Autore:
Smalley, JW; Birss, AJ; Silver, J;
Indirizzi:
Univ Liverpool, Dept Clin Dent Sci, Oral Biol Unit, Liverpool L69 3GN, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GN , Merseyside, England Univ Greenwich, Sch Chem & Life Sci, London SE18 6PF, England Univ Greenwich London England SE18 6PF ife Sci, London SE18 6PF, England
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 1, volume: 183, anno: 2000,
pagine: 159 - 164
SICI:
0378-1097(20000201)183:1<159:TPPPGH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMIN-BINDING; AQUEOUS-SOLUTION; W50; INACTIVATION; AGGREGATION; PORPHYRINS; PHYSIOLOGY; VIRULENCE; MOSSBAUER;
Keywords:
hydrogen peroxide; survival; iron protoporphyrin IX; haem; virulence; Porphyromonas gingivalis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Smalley, JW Univ Liverpool, Dept Clin Dent Sci, Oral Biol Unit, Edwards Bldg, Liverpool L69 3GN, Merseyside, England Univ Liverpool Edwards Bldg Liverpool Merseyside England L69 3GN
Citazione:
J.W. Smalley et al., "The periodontal pathogen Porphyromonas gingivalis harnesses the chemistry of the mu-oxo bishaem of iron protoporphyrin IX to protect against hydrogenperoxide", FEMS MICROB, 183(1), 2000, pp. 159-164

Abstract

The major haem component in the black pigment of Porphyromonas gingivalis is the mu-oxo bishaem of iron protoporphyrin IX and formation and cell-surface binding of this haem species is proposed as an extracellular buffer against reactive oxidants [Smalley, J.W. et al. (1998) Biochem. J. 331, 681-685], P. gingivalis cells grown in the presence of the mu-oxo bishaem were protected against H2O2 compared to control cells grown without it. When addedto the growth medium, soluble mu-oxo bishaem inactivated H2O2 and supported cell growth, Cells carrying a surface layer of mu-oxo bishaem were less susceptible to peroxidation by H2O2. Cell-surface haems were slowly destroyed during reaction with H2O2 Binding of mu-oxo bishaem by P. gingivalis may aid survival during neutrophil attack through inactivation of hydrogen peroxide, (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:36:23