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Titolo:
Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans
Autore:
Hazen, KC; Mandell, G; Coleman, E; Wu, GQ;
Indirizzi:
Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst Charlottesville VA USA 22908 sville, VA 22908 USA Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst Charlottesville VA USA 22908 sville, VA 22908 USA Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst Charlottesville VA USA 22908 sville, VA 22908 USA
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 1, volume: 183, anno: 2000,
pagine: 89 - 94
SICI:
0378-1097(20000201)183:1<89:IOFASC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGES; VIVO;
Keywords:
cell surface hydrophobicity; cell wall; phagocytosis; fluconazole; Candida albicans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hazen, KC Univ Virginia Hlth Syst, Dept Pathol, POB 214, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst POB 214 Charlottesville VA USA 22908 USA
Citazione:
K.C. Hazen et al., "Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans", FEMS MICROB, 183(1), 2000, pp. 89-94

Abstract

Cell surface hydrophobicity (CSH) status influences virulence of Candida albicans and decreases the susceptibility of yeast cells to phagocytic killing. We tested whether subinhibitory concentrations of fluconazole, which iswidely used in the treatment and prophylaxis of candidiasis, affect CSH and the susceptibility of C. albicans to enzymatic digestion by glucanase andto phagocytic killing. Treatment of yeast cells with subinhibitory fluconazole concentrations resulted in greater phagocytosis. This effect was independent of CSH but may be related to increased cell wail porosity resulting from alterations in the cell envelope. The use of subinhibitory concentrations of fluconazole in patients with competent phagocytes may contribute to resistance to candidiasis regardless of yeast CSH status. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 06:03:12