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Titolo:
Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor
Autore:
Rhee, MH; Nevo, I; Levy, R; Vogel, Z;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 466, anno: 2000,
pagine: 300 - 304
SICI:
0014-5793(20000128)466:2-3<300:ROTHCA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; 2ND INTRACELLULAR LOOP; SITE-DIRECTED MUTAGENESIS; BRADYKININ B2 RECEPTOR; ADENYLATE-CYCLASE; HORMONE RECEPTOR; ALPHA(1B)-ADRENERGIC RECEPTOR; SEQUENCE ALIGNMENT; AMINO-ACIDS; ACTIVATION;
Keywords:
cannabinoid CB2 receptor; G protein; site-directed mutagenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Vogel, Z Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
M.H. Rhee et al., "Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor", FEBS LETTER, 466(2-3), 2000, pp. 300-304

Abstract

The DRY motif, at the junction of transmembrane helix 3 and intracellular loop 2 of G protein-coupled receptors, is highly conserved. Mutations were introduced into the CB2 cannabinoid receptor to studs the role of this motif in CB2 signaling, D mutations (DPY130-132AAA and D130A) markedly reduced binding of cannabinoid agonists, while no significant reduction was observed sith R131A or Y132A. Mutating a (R131A) only partially reduced, and mutating Y (Y132A) more efficiently reduced the cannabinoid-induced inhibition of adenylyl cyclase. Thus, in CB2, D130 is involved in agonist binding, whereas Y seems to have a role in receptor downstream signaling, (C) 2000 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:11:33