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Titolo:
Requirements for alternative forms of the activator domain, P5abc, in the Tetrahymena ribozyme
Autore:
Naito, Y; Shiraishi, H; Inoue, T;
Indirizzi:
Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Grad Sch Biostudies, Kyoto 6068502, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 466, anno: 2000,
pagine: 273 - 278
SICI:
0014-5793(20000128)466:2-3<273:RFAFOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-SPLICING INTRONS; RNA INTERVENING SEQUENCE; GROUP-I RIBOZYME; TERTIARY INTERACTIONS; CATALYTIC CORE; SELECTION; SITE; ELEMENTS; EXCISION; PACKING;
Keywords:
ribozyme; P5abc; tertiary interaction; Tetrahymena;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan Kyoto UnivKyoto Japan 6068502 Biostudies, Kyoto 6068502, Japan
Citazione:
Y. Naito et al., "Requirements for alternative forms of the activator domain, P5abc, in the Tetrahymena ribozyme", FEBS LETTER, 466(2-3), 2000, pp. 273-278

Abstract

The role of P5abc domain of the Tetrahymena LSU self-splicing Group I intron is to enhance the activity of the intron via tertiary interactions involving A-rich bulge and terminal loops L5b and L5c, We constructed and examined alternative forms of the domain that accelerate the ribozymatic reaction. The results indicate that the characteristic structure of P5c subdomain plays an important role by forming L2XL5c interaction (P14) and that the region flanking P5c subdomain can be significantly mutable without much affecting the activity of the ribozyme. (C) 2000 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:20:43