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Titolo:
Comparison of two standardized methods of methacholine inhalation challenge in young adults
Autore:
Siersted, HC; Walker, CM; OShaughnessy, AD; Willan, AR; Wiecek, EM; Sears, MR;
Indirizzi:
McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada er Univ, Dept Med, Hamilton, ON, Canada McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada idemiol & Biostat, Hamilton, ON, Canada
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 15, anno: 2000,
pagine: 181 - 184
SICI:
0903-1936(200001)15:1<181:COTSMO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; INHALED HISTAMINE; REACTIVITY; PREVALENCE; CHILDREN; SYMPTOMS; ATOPY;
Keywords:
airway hyperresponsiveness; asthma; epidemiology; methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sears, MR St Josephs Hosp, Firestone Reg Chest & Allergy Unit, 50 CharitonAve E, Hamilton, ON L8N 4A6, Canada St Josephs Hosp 50 Chariton Ave E Hamilton ON Canada L8N 4A6 ada
Citazione:
H.C. Siersted et al., "Comparison of two standardized methods of methacholine inhalation challenge in young adults", EUR RESP J, 15(1), 2000, pp. 181-184

Abstract

In the European Community Respiratory Health Study (ECRHS), airway responsiveness to methacholine was determined using the Mefar dosimeter protocol. Elsewhere, the 2-min tidal breathing method has become the preferred standardized method. The relationship between measurements of responsiveness by these two methods is not well established. This study measured airway responsiveness to methacholine by dosimeter andtidal breathing methods in 47 healthy asthmatic subjects aged 20-44 yrs. Tests were performed within 1 week and in random order. Baseline forced expiratory volume in one second (FEV1) varied by <10% between tests in 42/47 subjects. There was a close association between responsiveness determined by the two methods. A provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) value of less than or equal to 8.0mg.mL(-1) (tidal method) used to categorize airway hyper-responsiveness agreed most closely with a provocative dose of methacholine causing a 20% fall in FEV1 (PD20) value of less than or equal to 0.5 mg (dosimeter method) (kappa statistic 0.78). Each doubling or halving of PC20 to define a level of hyperresponsiveness agreed closely with a doubling or halving of PD20. Assessment of airway responsiveness as provocative dose of methacholine causing a 20% fall in forced expiratory volume in one second by the Mefar dosimeter protocol gave a close and predictable relationship with provocative concentration of methacholine causing a 20% fall in expiratory volume in one second assessed using the tidal breathing method. Airway hyperresponsiveness as determined by the accepted criterion of provocative concentration ofmethacholine causing a 20% fall in expiratory volume in one second less than or equal to 8 mg.mL(-1) was best correlated with provocative dose of methacholine causing a 20% fall in forced expiratory volume in one second <0.5mg by Mefar dosimeter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:23:43