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Titolo:
The association between early life lung function and wheezing during the first 2 yrs of life
Autore:
Young, S; Arnott, J; OKeeffe, PT; Le Souef, PN; Landau, LI;
Indirizzi:
Princess Margaret Hosp Children, Dept Resp Med, Perth, WA, Australia Princess Margaret Hosp Children Perth WA Australia Perth, WA, Australia
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 15, anno: 2000,
pagine: 151 - 157
SICI:
0903-1936(200001)15:1<151:TABELL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-TRACT ILLNESS; FORCED EXPIRATORY FLOWS; BRONCHIAL RESPONSIVENESS; EARLY-CHILDHOOD; 1ST YEAR; AIRWAY RESPONSIVENESS; PARENTAL SMOKING; NORMAL INFANTS; RISK FACTOR; ASTHMA;
Keywords:
early childhood wheeze; infant airway responsiveness; infant lung function; influence of maternal tobacco smoking; influence of parental asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Landau, LI Univ Western Australia, Fac Med & Dent, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 7, Australia
Citazione:
S. Young et al., "The association between early life lung function and wheezing during the first 2 yrs of life", EUR RESP J, 15(1), 2000, pp. 151-157

Abstract

Reports have suggested that certain infants are predisposed to wheezing inthe first 2 yrs of life due to abnormal lung function, prior to the first wheezing illness. The authors investigated the association between infant lung function and wheeze during the first 2 yrs of life. A cohort of 253 infants was evaluated. Respiratory function assessment wasperformed at 1, 6, and 12 months of age. Parental history of asthma, atopy, and maternal antenatal smoking habits were recorded. An infant was identified as having wheezed on the basis of parental report and, where possible,physician diagnosis. One hundred and sixty infants (63%) had complete diary and questionnaire information on wheeze available for analysis. Of these:79 infants (50%) had never wheezed (NW) during the first 2 yrs of life and81 had reported wheeze (W) (50%). Of those with a report of wheeze, the distribution through the first 2 yrsof life was; 28 during the first year of life only (Y1), 21 in the second year of life only (Y2), and 32 wheezed in both the first and second years of life (Y1&2). At the age of 1 month, prior to any lower respiratory illness, the W grouphad impaired lung function in comparison to the NW group. In Y1 infants, the neonatal lung function differences resolved by 12 months of age. In Y2 and Y1&2 infants lung function differences persisted throughout the first year of life. Prevalence of parental asthma and maternal antenatal smoking was increased in the W group p=0.001, p=0.008, respectively), in comparison to the NW infants. Maternal antenatal smoking prevalence was increased in the Y2 and Y1&2 infants in comparison to the NW group (p=0.04), (p=0.01), respectively. Wheezing during the first year of life is often a transient condition which improves with time. It appears to be related to early life reduced small airway calibre. Wheezing that begins or persists into the second year of life is usually associated with a different abnormality of the airways. Commencement or persistence of wheeze into the second year of life may be part of the clinical entity recognized as asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:09:38