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Titolo:
Leukotoxin and its diol induce neutrophil chemotaxis through signal transduction different from that of fMLP
Autore:
Totani, Y; Saito, Y; Ishizaki, T; Sasaki, F; Ameshima, S; Miyamori, I;
Indirizzi:
Fukui Med Univ, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Univ Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan Fujita Hlth Univ, Dept Internal Med, Div Pulm & Allergy Med, Aichi, Japan Fujita Hlth Univ Aichi Japan Med, Div Pulm & Allergy Med, Aichi, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 15, anno: 2000,
pagine: 75 - 79
SICI:
0903-1936(200001)15:1<75:LAIDIN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTES; SUPEROXIDE ANION; PATHWAY; KINASE;
Keywords:
acute lung injury; leukotoxin; leukotoxin diol; neutrophil chemotaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Totani, Y Fukui Med Univ, Dept Internal Med 3, Mastuoka Cho, Fukui 91011, Japan Fukui Med Univ Mastuoka Cho Fukui Japan 91011 ukui 91011, Japan
Citazione:
Y. Totani et al., "Leukotoxin and its diol induce neutrophil chemotaxis through signal transduction different from that of fMLP", EUR RESP J, 15(1), 2000, pp. 75-79

Abstract

When injected into animals, leukotoxin (Lx) causes acute lung injury whichis associated with neutrophils infiltrating the lung tissues. However, theeffect of Lx on neutrophils is still unknown, and recently it has been reported that Lx diol, a hydrolyzed metabolite, should be more potent than Lx in vitro. In this study, the authors examined the effect of Lx and its diolon human neutrophils by assessing their chemotactic response, expression of adhesion molecules, and production of peroxides. Both Lx and its diol induced chemotaxis in human neutrophils via an involvement of pertussis toxin-sensitive G-proteins, but they did not influence the expression of adhesion molecules or the production of peroxides, Furthermore, Lx synergistically affected chemotaxis with N-formyl-methionyl-leucyl-phenylalanine (fMLP), but not,vith endothelin-1. Neutrophil chemotaxis induced by both Lx and its diol was inhibited by phosphatidylinositol-3-kinase (P13-K) inhibitors, but not by protein tyrosine kinase (PTK) inhibitors or by protein kinase C (PKC) inhibitors, whereas fMLP-induced chemotakis was inhibited by PTK inhibitors, but not by P13-K inhibitors or by PKC inhibitors. These results suggest that neutrophil chemotaxis induced by both Lx and its diet involves pathways different from those induced by fMLP. In conclusion, both leukotoxin and its diol metabolite induce chemotaxis in human neutrophils in a unique way and may act as important bioactive lipids when considering the pathological mechanism of acute lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:02:22