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Titolo:
INTRAVASCULAR OXYGEN DISTRIBUTION IN SUBCUTANEOUS 9L TUMORS AND RADIATION SENSITIVITY
Autore:
CERNIGLIA GJ; WILSON DF; PAWLOWSKI M; VINOGRADOV S; BIAGLOW J;
Indirizzi:
UNIV PENN,DEPT BIOCHEM & BIOPHYS,SCH MED,RM 426,ANAT CHEM BLDG PHILADELPHIA PA 19104 UNIV PENN,DEPT BIOCHEM & BIOPHYS,SCH MED PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIAT ONCOL,SCH MED PHILADELPHIA PA 19104 MED SYST CORP GREENVALE NY 11548
Titolo Testata:
Journal of applied physiology
fascicolo: 6, volume: 82, anno: 1997,
pagine: 1939 - 1945
SICI:
8750-7587(1997)82:6<1939:IODIS9>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; CELLULAR-ENERGY METABOLISM; BLOOD-FLOW; TISSUE OXYGENATION; INDUCED BINDING; OPTICAL METHOD; HYPOXIC CELLS; DEPENDENCE; MISONIDAZOLE; CANCER;
Keywords:
PHOSPHORESCENCE; IMAGING; GLIOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Cerniglia et al., "INTRAVASCULAR OXYGEN DISTRIBUTION IN SUBCUTANEOUS 9L TUMORS AND RADIATION SENSITIVITY", Journal of applied physiology, 82(6), 1997, pp. 1939-1945

Abstract

Phosphorescence quenching was evaluated as a technique for measuring Po-2 in tumors and for determining the effect of increased Po-2 on sensitivity of the tumors to radiation. Suspensions of cultured 9L cells or small pieces of solid tumors from 9L cells were injected subcutaneously on the hindquarter of rats, and tumors were grown to between 0.2 and 1.0 cm in diameter. Oxygen-dependent quenching of the phosphorescence of intravenously injected Pd-meso-tetra-(4-carboxyphenyl) porphinewas used to image the in vivo distribution of Po-2 in the vasculatureof small tumors and surrounding tissue. Maps (512 x 480 pixels) of tissue oxygen distribution showed that the Po-2 within 9L tumors was low(2-12 Torr) relative to the surrounding muscle tissue (20-40 Torr). When the rats were given 100% oxygen or carbogen (95% O-2-5% CO2) to breathe, the Po-2 in the tumors increases significantly. This increase was variable among tumors and was greater with carbogen compared with 100% oxygen. Based on irradiation and regrowth studies, carbogen breathing increased the sensitivity of the tumors to radiation. This is consistent with the measured increase in Po-2 in the tumor vasculature. Itis concluded that phosphorescence quenching can be used for noninvasive determination of the oxygenation of tumors. This method for oxygen measurements has great potential for clinical application in tumor identification and therapy.

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Documento generato il 09/04/20 alle ore 07:46:43