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Titolo:
IMPROVED FATIGUE RESISTANCE NOT ASSOCIATED WITH MAXIMUM OXYGEN-CONSUMPTION IN CREATINE-DEPLETED RATS
Autore:
TANAKA T; OHIRA Y; DANDA M; HATTA H; NISHI I;
Indirizzi:
NATL INST FITNESS & SPORTS,DEPT PHYSIOL & BIOMECH KANOYA KAGOSHIMA 89123 JAPAN NATL INST FITNESS & SPORTS,DEPT PHYSIOL & BIOMECH KANOYA KAGOSHIMA 89123 JAPAN UNIV TOKYO,COLL ARTS & SCI,DEPT SPORTS SCI TOKYO 153 JAPAN SCI UNIV TOKYO,FAC SCI & TECHNOL,DEPT PHYS NODA CHIBA 278 JAPAN
Titolo Testata:
Journal of applied physiology
fascicolo: 6, volume: 82, anno: 1997,
pagine: 1911 - 1917
SICI:
8750-7587(1997)82:6<1911:IFRNAW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GUANIDINOPROPIONIC ACID; SKELETAL-MUSCLE; EXERCISE; ADAPTATION; RESPONSES; PHOSPHOCREATINE; DEHYDROGENASE; TRANSITIONS; CAPACITY; INCREASE;
Keywords:
ENDURANCE CAPACITY; HIGH-ENERGY PHOSPHATE CONTENTS; GLYCOGEN; MITOCHONDRIAL ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Tanaka et al., "IMPROVED FATIGUE RESISTANCE NOT ASSOCIATED WITH MAXIMUM OXYGEN-CONSUMPTION IN CREATINE-DEPLETED RATS", Journal of applied physiology, 82(6), 1997, pp. 1911-1917

Abstract

Effects of feeding of either creatine or its analog beta-guanidinopropionic acid (beta-GPA) on endurance work capacity and oxygen consumption were studied in rats. Resting high-energy phosphate contents in hindlimb muscles were lower in the beta-GPA group and higher in the creatine group than in controls. The glycogen contents in resting hindlimb muscles of rats fed beta-GPA were significantly higher than those in controls. The endurance run and swimming times to exhaustion were significantly greater (32-70%) in the beta-GPA group than in the control and creatine groups. However, there were no beneficial effects on the maximum oxygen consumption ((V) over dotO(2max)) and oxygen transport capacity of blood by the feeding of beta-GPA. None of these parameters were significantly influenced by creatine supply. Both maximum exercisetime and (V) over dotO(2max) in the beta-GPA group were not changed by normalization of glycogen levels. The activities of mitochondrial enzymes in skeletal muscles were higher in the beta-GPA group than in the controls. Thus endurance capacity is improved if the respiratory capacity of muscles is increased, even when the contents of high-energy phosphates in muscles are lower. Increased endurance capacity was not directly associated with the elevated levels of muscle glycogen, oxygentransport capacity of blood, or (V) over dotO(2max).

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Documento generato il 13/08/20 alle ore 11:31:40