Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacodynamic aspects of modes of drug administration for optimization of drug therapy
Autore:
Hoffman, A; Stepensky, D;
Indirizzi:
Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmaceut, Fac Med, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel
Titolo Testata:
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
fascicolo: 6, volume: 16, anno: 1999,
pagine: 571 - 639
SICI:
0743-4863(1999)16:6<571:PAOMOD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-LACTAM ANTIBIOTICS; LONG-TERM TREATMENT; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; DENSITY-LIPOPROTEIN CHOLESTEROL; SUBCUTANEOUS INSULIN INFUSION; DEPENDENT DIABETIC-PATIENTS; CHRONIC RENAL-INSUFFICIENCY; ADVANCED COLORECTAL-CANCER; GASTRIC-ACID SECRETION; HIGH-DOSE RANITIDINE;
Keywords:
pharmacodynamics; pharmacokinetics; mode of drug administration; delayed action preparations; tolerance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
237
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffman, A Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmaceut, Fac Med, POB12065, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem POB 12065 Jerusalem Israel IL-91120 rael
Citazione:
A. Hoffman e D. Stepensky, "Pharmacodynamic aspects of modes of drug administration for optimization of drug therapy", CR R THER, 16(6), 1999, pp. 571-639

Abstract

Because of various pharmacodynamic properties, such as the nonlinearity ofthe concentration-effect relationship, activation of feedback homeostatic mechanisms, induction of pharmacodynamic tolerance, etc., administration ofthe same dose of drug by different modes is expected to produce different outcomes. This review clarifies the theoretical and practical aspects of the impact of different modes of drug administration on the magnitude of response, and hence on therapy outcomes. It discusses how the interrelationshipbetween the pharmacodynamic properties and the drug input function affectsthe magnitude of response. To demonstrate this special dimension of drug therapy, relevant pharmacodynamic data was obtained for drugs with differenttherapeutic applications, including antibiotics, analgesics, diuretics, anti-cancer, anti-ulcer, anti-inflammatory, antihypertensive, lipid-lowering anti-parkinsonian, and immunosuppressive drugs. These examples provide guidelines for implementing the role of the mode of drug administration (including: rate, schedule, and route of drug treatment) during drug development or optimization of drug therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 20:50:08