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Titolo:
Lack of residual sedation following middle-of-the-night zaleplon administration in sleep maintenance insomnia
Autore:
Walsh, JK; Pollak, CP; Scharf, MB; Schweitzer, PK; Vogel, GW;
Indirizzi:
St Lukes Hosp, Sleep Med & Res Ctr, Chesterfield, MO 63017 USA St Lukes Hosp Chesterfield MO USA 63017 s Ctr, Chesterfield, MO 63017 USA St Louis Univ, Dept Psychiat, St Louis, MO 63103 USA St Louis Univ St Louis MO USA 63103 Dept Psychiat, St Louis, MO 63103 USA Ohio State Univ, Dept Neurol, Div Sleep Med, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 v Sleep Med, Columbus, OH 43210 USA Ctr Res Sleep Disorders, Cincinnati, OH USA Ctr Res Sleep Disorders Cincinnati OH USA Disorders, Cincinnati, OH USA Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 niv, Dept Psychiat, Atlanta, GA 30322 USA Sleep Res Lab Inc, Atlanta, GA USA Sleep Res Lab Inc Atlanta GA USASleep Res Lab Inc, Atlanta, GA USA
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 1, volume: 23, anno: 2000,
pagine: 17 - 21
SICI:
0362-5664(200001/02)23:1<17:LORSFM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZOLPIDEM; TRIAZOLAM;
Keywords:
zaleplon; residual sedation; insomnia; hypnotic medication;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Walsh, JK St Lukes Hosp, Sleep Med & Res Ctr, 232 S Woods Mill Rd, Chesterfield, MO 63017 USA St Lukes Hosp 232 S Woods Mill Rd Chesterfield MO USA 63017 USA
Citazione:
J.K. Walsh et al., "Lack of residual sedation following middle-of-the-night zaleplon administration in sleep maintenance insomnia", CLIN NEUROP, 23(1), 2000, pp. 17-21

Abstract

The present randomized, double-blind, placebo and active-drug controlled, crossover study assessed residual sedation after zaleplon 10 mg, flurazepam30 mg (as an active control), and placebo, taken during a nocturnal awakening in patients with sleep maintenance insomnia. Twenty-two healthy sleep maintenance insomniacs (11 men; mean age, 42 y) received zaleplon, flurazepam, or placebo after an experimental awakening 3.5 hours after bedtime on two consecutive nights in each of three conditions. Residual sedation was measured with sleep latency testing (5 and 6.5 h postdrug), digit symbol substitution, symbol copying, and subjective sleepiness by visual analog scale, each twice each morning. Zaleplon did not differ from placebo on any measure of residual sedation; flurazepam showed significant sedation on all measures. No residual sedative effects were detected 5 or 6.5 hours after ingestion of zaleplon during the middle of the night by sleep maintenance insomniacs.

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Documento generato il 04/12/20 alle ore 13:04:46