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Titolo:
High density lipoproteins (HDL) and the oxidative hypothesis of atherosclerosis
Autore:
Bonnefont-Rousselot, D; Therond, P; Beaudeux, JL; Peynet, J; Legrand, A; Delattre, J;
Indirizzi:
Univ Paris 05, Fac Pharm, Lab Biochim Metab & Clin, F-75270 Paris 06, France Univ Paris 05 Paris France 06 him Metab & Clin, F-75270 Paris 06, France
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 10, volume: 37, anno: 1999,
pagine: 939 - 948
SICI:
1434-6621(199910)37:10<939:HDL(AT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; ACTIVATING FACTOR-ACETYLHYDROLASE; LIPID-PEROXIDATION PRODUCTS; COPPER-CATALYZED OXIDATION; BILIARY STEROL SECRETION; HUMAN BLOOD-PLASMA; SERUM PARAOXONASE; ALPHA-TOCOPHEROL; TRANSGENIC MICE;
Keywords:
atherosclerosis; high density lipoproteins; low density lipoproteins; lipid peroxidation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Bonnefont-Rousselot, D Univ Paris 05, Fac Pharm, Lab Biochim Metab & Clin,4 Ave Observ, F-75270 Paris 06, France Univ Paris 05 4 Ave Observ Paris France 06 France
Citazione:
D. Bonnefont-Rousselot et al., "High density lipoproteins (HDL) and the oxidative hypothesis of atherosclerosis", CLIN CH L M, 37(10), 1999, pp. 939-948

Abstract

The oxidative hypothesis of atherosclerosis classically implies a central role for low density lipoprotein (LDL) oxidation. However, new antiatherogenic properties have been recognized for high density lipoproteins (HDL), apart from their ability to reverse cholesterol transport. Indeed, native HDLcould protect LDL from oxidation, thereby minimizing the deleterious consequences of this process. Several mechanisms have been suggested to explain this protective role. Two HDL-associated enzymes, paraoxonase and PAF-acetylhydrolase, detoxify oxidized phospholipids produced by lipid peroxidation. In addition, HDL could reduce hydroperoxides to their corresponding hydroxides. It has also been suggested that HDL could inhibit oxidized LDL-induced transduction signals. However, in vivo HDL oxidation in the subendothelial space would favor the atherosclerotic process. Indeed, atherogenic properties of these oxidized HDL partly result from some loss of their cholesterol effluxing capacity and from an inactivation of the lecithin-cholesterol acyltransferase, which is a HDL-associated enzyme involved in reverse cholesterol transport. Finally, oxidized HDL could induce cholesterol accumulation in macrophages. Further in-depth investigation is needed to assess these antagonistic effects and their consequences for the atherosclerotic process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:47:58