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Titolo:
Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure
Autore:
van Lieshout, JJ; ten Harkel, ADJ; Wieling, W;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1100 DE Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 DE E Amsterdam, Netherlands Cardiovasc Res Inst Amsterdam, Amsterdam, Netherlands Cardiovasc Res Inst Amsterdam Amsterdam Netherlands terdam, Netherlands
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 1, volume: 10, anno: 2000,
pagine: 35 - 42
SICI:
0959-9851(200002)10:1<35:FASITH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOSTATIC HYPOTENSION; BLOOD-PRESSURE; CARDIOVASCULAR REFLEXES; SALT INTAKE; TILT; ARTERIAL; HUMANS;
Keywords:
blood pressure; stroke volume; vascular resistance; body fluids; hormones; plethysmography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: van Lieshout, JJ Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Room F4-264,POB 22700, NL-1100 DE Amsterdam, Netherlands Univ Amsterdam Room F4-264,POB 22700 Amsterdam Netherlands NL-1100 DE
Citazione:
J.J. van Lieshout et al., "Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure", CLIN AUTON, 10(1), 2000, pp. 35-42

Abstract

Treatment with head-up tilt sleeping and low-dose fludrocortisone effectively minimizes orthostatic symptoms and increases orthostatic blood pressurein patients with neurogenic orthostatic hypotension. The aim of the present study was to examine whether the improvement in orthostatic blood pressure during combined treatment with low-dose fludrocortisone and nocturnal head-up tilt in patients with neurogenic orthostatic hypotension can be attributed to expansion of plasma volume or to increased total peripheral resistance. The effects of a 3-week treatment with fludrocortisone and nocturnal head-up tilting on the postural changes in arterial pressure, heart rate, and cardiac output (pulse contour) were evaluated in eight consecutive patients with orthostatic hypotension. The period during which the patients were able to remain in the standing position without orthostatic complaints increased minimally from 3 to 10 minutes. The decrease in arterial pressure after 1 minute of standing-(means with standard deviations in parentheses) systolic, 49 (20) mm Hg; diastolic,18 (11) mm Hg-before treatment was produced by a greater than normal decrease in cardiac output: 37% (10%) in patients with neurogenic orthostatic hypotension versus -14% (8%) in control subjects, Treatment increased uprightarterial pressure from 83 (19) mm Hg systolic and 55 (13) mm Hg diastolic to 114 (22) mm Hg systolic and 60 (16) mm Hg diastolic by limiting the decrease in cardiac output. Body weight increased but hematocrit did not change. Leg pressure-volume relationship decreased in the two patients studied. The responses of plasma renin activity and aldosterone to orthostatic stressprior to treatment were subnormal and became even lower after treatment. The improvement in upright blood pressure in orthostatic hypotension during treatment with fludrocortisone and nocturnal head-up sleeping is the result of a reduction in the orthostatic decrease in cardiac output. Preliminary data suggest that the expanded body fluid volume is allocated to the perivascular space rather than to the intravascular space.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:22:39