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Titolo:
The presser response to water drinking in humans - A sympathetic reflex?
Autore:
Jordan, J; Shannon, JR; Black, BK; Ali, Y; Farley, M; Costa, F; Diedrich, A; Robertson, RM; Biaggioni, I; Robertson, D;
Indirizzi:
Vanderbilt Univ, Autonom Dysfunct Ctr, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 funct Ctr, Nashville, TN 37232 USA Vanderbilt Univ, Dept Cardiol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 t Cardiol, Nashville, TN 37232 USA Vanderbilt Univ, Nathan Blaser Shy Drager Res Program, Nashville, TN 37232USA Vanderbilt Univ Nashville TN USA 37232 es Program, Nashville, TN 37232USA Franz Volhard Clin, Clin Res Ctr, Berlin, Germany Franz Volhard Clin Berlin Germany d Clin, Clin Res Ctr, Berlin, Germany
Titolo Testata:
CIRCULATION
fascicolo: 5, volume: 101, anno: 2000,
pagine: 504 - 509
SICI:
0009-7322(20000208)101:5<504:TPRTWD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC FAILURE; NERVOUS-SYSTEM; NOREPINEPHRINE; YOHIMBINE; RELEASE;
Keywords:
blood pressure; norepinephrine; water;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, D Vanderbilt Univ, Autonom Dysfunct Ctr, AA3228 MCN, Nashville,TN 37232 USA Vanderbilt Univ AA3228 MCN Nashville TN USA 37232 N 37232 USA
Citazione:
J. Jordan et al., "The presser response to water drinking in humans - A sympathetic reflex?", CIRCULATION, 101(5), 2000, pp. 504-509

Abstract

Background-Water drinking increases blood pressure profoundly in patients with autonomic failure and substantially in older control subjects. The mechanism that mediates this response is not known. Methods ana Results-We studied the effect of drinking tap water on seated blood pressure in 47 patients with severe autonomic failure (28 multiple system atrophy [MSA], 19 pure autonomic failure patients [PAF]). Eleven oldercontrols and 8 young controls served as control group. We also studied themechanisms Chat could increase blood pressure with water drinking. Systolic blood pressure increased profoundly with water drinking, reaching a maximum of 33+/-5 mm Hg in MSA and 37+/-7 in PAF mm Hg after 30 to 35 minutes. The presser response was greater in patients with more retained sympathetic function and was almost completely abolished by trimethaphan infusion. Systolic blood pressure increased by 11+/-2.4 mm Hg in elderly but not in youngcontrols. Plasma norepinephrine increased in both groups. Plasma renin activity, vasopressin, and blood volume did not change in any group. Conclusions-Water drinking significantly and rapidly raises sympathetic activity. Indeed, it raises plasma norepinephrine as much as such classic sympathetic stimuli as caffeine and nicotine. This effect profoundly increasesblood pressure in autonomic failure patients, and this effect can be exploited to improve symptoms due to orthostatic hypotension. Water drinking also acutely raises blood pressure in older normal subjects. The presser effect of oral water is an important yet unrecognized confounding factor in clinical studies of presser agents and antihypertensive medications. (Circulation. 2000;101:504-509.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:01:53