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Titolo:
Cultured murine parenchymal liver cells induce differentiation of bone marrow cells to macrophage like cells which present antigen to TH1 clones but inhibit their proliferation by nitric oxide and prostaglandinsa
Autore:
Mabuchi, A; Shimizu, M; Kikuchi, K; Nakagawa, Y; Takahashi, H; Kakiuchi, T; Yokomuro, K;
Indirizzi:
Nippon Med Sch, Dept Microbiol & Immunol, Bunkyo Ku, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 ol & Immunol, Bunkyo Ku, Tokyo 113, Japan
Titolo Testata:
CELLS OF THE HEPATIC SINUSOID, VOL 7
, , anno: 1999,
pagine: 267 - 269
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-PROLIFERATION; SUPPRESSION; HEPATOCYTES; TOLERANCE; RESPONSES;
Tipo documento:
Article
Natura:
Monografia
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mabuchi, A Nippon Med Sch, Dept Microbiol & Immunol, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 113, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 113 Tokyo 113, Japan
Citazione:
A. Mabuchi et al., "Cultured murine parenchymal liver cells induce differentiation of bone marrow cells to macrophage like cells which present antigen to TH1 clones but inhibit their proliferation by nitric oxide and prostaglandinsa", CELLS OF THE HEPATIC SINUSOID, VOL 7, 1999, pp. 267-269

Abstract

Suppressor cells were developed from nylon-wool non-adherent CD4(-)8(-)TCRbeta, bone marrow cells (TN-NWP-BMC) co-cultured with parenchymal liver cells (PLC) for 2.5 days. The major suppressor cell population consists of nylon-wool/plastic dish adherent, phagocytic Mac-1(+) CD3(-)4(-)8(-)cells (Adcells), with 34% of the Ad cells being F4/80(+) and 24% Ia(+). These cellssupressed the antigen specific proliferation of Th1 clones in an MHC-non-restricted manner. They showed a dose-dependent increase in suppressive activity, with both the nitric oxide (NO) and prostaglandin E-2 (PGE(2)) levelsin the culture supernatant rising with Ad cell concentration. If Ad cells did actually exist in the liver sinusoid, they would thus be bound to play a major role in inducing peripheral tolerance by the liver.

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Documento generato il 02/04/20 alle ore 19:03:55