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Titolo:
Baroreflex dependent and independent roles of the caudal ventrolateral medulla in cardiovascular regulation
Autore:
Sved, AF; Ito, S; Madden, CJ;
Indirizzi:
Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 2, volume: 51, anno: 2000,
pagine: 129 - 133
SICI:
0361-9230(20000115)51:2<129:BDAIRO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; SPONTANEOUSLY HYPERTENSIVE RATS; BLOOD-PRESSURE; L-GLUTAMATE; BRAIN-STEM; BAROSENSITIVE NEURONS; BARORECEPTOR REFLEXES; VENTRAL SURFACE; DENERVATED RATS; ACID;
Keywords:
A1 area; baroreceptor; hypertension; spontaneously hypertensive rats; sympathoinhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sved, AF Univ Pittsburgh, Dept Neurosci, 446 Crawford Hall, Pittsburgh, PA15260 USA Univ Pittsburgh 446 Crawford Hall Pittsburgh PA USA 15260 260 USA
Citazione:
A.F. Sved et al., "Baroreflex dependent and independent roles of the caudal ventrolateral medulla in cardiovascular regulation", BRAIN RES B, 51(2), 2000, pp. 129-133

Abstract

The caudal ventrolateral medulla (CVLM) plays a critical role in cardiovascular regulation. Convincing data now support the hypothesis that inhibition of sympathoexcitatory neurons in the rostral ventrolateral medulla (RVLM)by CVLM neurons constitutes the necessary inhibitory link in baroreceptor reflex mediated control of sympathetic vasomotor outflow. Inhibition or destruction of the CVLM produces severe acute hypertension, consistent with blockade of baroreceptor reflexes and withdrawal of inhibition of RVLM sympathoexcitatory neurons. However, other data indicate that the CVLM also tonically inhibits RVLM sympathoexcitatory neurons in a manner not driven by baroreceptor input. In some studies, inhibition of the CVLM results in an increase in arterial pressure (AP) without inhibiting baroreceptor reflexes, possibly reflecting baroreceptor-independent and baroreceptor-dependent sub-regions of the CVLM. Furthermore, in baroreceptor-denervated rats, inhibition of the CVLM still leads to large increases in AP. In addition, in spontaneously hypertensive rats (SHR) central processing of baroreceptor reflexes appears normal but CVLM-mediated inhibition of the RVLM seems to be attenuated, suggesting that it is specifically a baroreceptor-independent mechanism of cardiovascular regulation in SHR that is altered. Taken together, these findings support an important, tonic, baroreceptor-independent inhibitionof RVLM sympathoexcitatory neurons exerted by the CVLM. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:46:08