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Titolo:
Angiotensin peptides and baroreflex control of sympathetic outflow: Pathways and mechanisms of the medulla oblongata
Autore:
Averill, DB; Diz, DI;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Hypertens & Vasc Dis Ctr, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 2, volume: 51, anno: 2000,
pagine: 119 - 128
SICI:
0361-9230(20000115)51:2<119:APABCO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ROSTRAL VENTROLATERAL MEDULLA; NUCLEUS TRACTUS SOLITARIUS; BARORECEPTOR REFLEX MODULATION; CONVERTING-ENZYME-INHIBITOR; II RECEPTOR-BINDING; SUBSTANCE-P; BLOOD-PRESSURE; NERVE ACTIVITY; HEART-RATE;
Keywords:
angiotensin peptides; angiotensin II; angiotensin(1-7); sympathetic nervous system; baroreflex; nucleus tractus solitarius; ventrolateral medulla; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Averill, DB Wake Forest Univ, Bowman Gray Sch Med, Hypertens & Vasc Dis Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 7 USA
Citazione:
D.B. Averill e D.I. Diz, "Angiotensin peptides and baroreflex control of sympathetic outflow: Pathways and mechanisms of the medulla oblongata", BRAIN RES B, 51(2), 2000, pp. 119-128

Abstract

The baroreceptor reflex is a relatively high gain control system that maintains arterial pressure within normal limits. To a large extent, this is accomplished through central neural pathways responsible for autonomic outflow residing in the medulla oblongata. The circulating renin-angiotensin system also contributes to the regulation of blood pressure, predominantly through its effects on the control of hydromineral balance and fluid volume. All the components of the renin-angiotensin system are also found in the brain. One of the principal products of the renin-angiotensin system cascade (brain or blood), angiotensin II, modulates the baroreceptor reflex by diminishing the sensitivity of the reflex and shifting the operating point for regulation of sympathetic outflow to higher blood pressures. This paper reviews our current knowledge about the neuronal pathways in the medulla oblongata through which angiotensin peptides alter the baroreceptor reflex controlof sympathetic nerve activity. Emphasis is placed on the probable components and neural mechanisms of the medullary baroreflex are that account for the ability of angiotensin peptides to change the sensitivity of the baroreceptor reflex and to shift the baroreceptor reflex control of sympathetic outflow to higher blood pressures in a pressure-independent manner. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:31:04