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Titolo:
Anatomical substrates for baroreflex sympathoinhibition in the rat
Autore:
Aicher, SA; Milner, TA; Pickel, VM; Reis, DJ;
Indirizzi:
Cornell Univ Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY10021 USA Cornell Univ Med Coll New York NY USA 10021 urosci, New York, NY10021 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 2, volume: 51, anno: 2000,
pagine: 107 - 110
SICI:
0361-9230(20000115)51:2<107:ASFBSI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; SYMPATHETIC PREGANGLIONIC NEURONS; NUCLEUS-TRACTUS-SOLITARIUS; AORTIC BARORECEPTOR REFLEXES; C1 ADRENERGIC-NEURONS; NMDA RECEPTORS; MONOSYNAPTIC PROJECTIONS; BAROSENSITIVE NEURONS; ADRENALINE NEURONS; TERMINALS SYNAPSE;
Keywords:
cardiovascular; blood pressure; nucleus tractus solitarius; caudal ventrolateral medulla; rostral ventrolateral medulla; ultrastructure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Aicher, SA Cornell Univ Med Coll, Div Neurobiol, Dept Neurol & Neurosci, 411 E 69th St, New York, NY 10021 USA Cornell Univ Med Coll 411 E 69th St New York NY USA 10021 1 USA
Citazione:
S.A. Aicher et al., "Anatomical substrates for baroreflex sympathoinhibition in the rat", BRAIN RES B, 51(2), 2000, pp. 107-110

Abstract

The fundamental neuronal substrates of the arterial baroreceptor reflex have been elucidated by combining anatomical, neurophysiological, and pharmacological approaches. A serial pathway between neurons located in the nucleiof the solitary tract (NTS), the caudal ventrolateral medulla (CVL), and the rostral ventrolateral medulla (RVL) plays a critical role in inhibition of sympathetic outflow following stimulation of baroreceptor afferents, In this paper, we summarize our studies using tract-tracing and electron microscopic immunocytochemistry to define the potential functional sites for synaptic transmission within this circuitry. The results are discussed as theyrelate to the literature showing: (1) baroreceptor afferents excite second-order neurons in NTS through the release of glutamate; (2) these NTS neurons in turn send excitatory projections to neurons in the CVL; (3) GABAergicCVL neurons directly inhibit RVL sympathoexcitatory neurons; and (4) activation of this NTS-->CVL-->RVL pathway leads to disfacilitation of sympathetic preganglionic neurons by promoting withdrawal of their tonic excitatory drive, which largely arises from neurons in the RVL, Baroreceptor control may also be regulated over direct reticulospinal pathways exemplified by a newly recognized sympathoinhibitory region of the medulla, the gigantocellular depressor area. This important autonomic reflex may also be influenced by parallel, multiple, and redundant networks. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:17:38