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Titolo:
Activation of cardiac vagal afferents facilitates late vagal inhibition inneurones of the rostral ventrolateral medulla oblongata bilaterally
Autore:
Zagon, A;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Physiol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 854, anno: 2000,
pagine: 172 - 177
SICI:
0006-8993(20000131)854:1-2<172:AOCVAF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; RENAL NERVE ACTIVITY; RAT; PROJECTIONS; BARORECEPTOR; STIMULATION; VAGUS; DOGS;
Keywords:
intracellular recording; myocardial infarction; rat; slow hyperpolarisation; vagus; ventrolateral medulla oblongata;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Zagon, A Royal Free & Univ Coll Med Sch, Dept Physiol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF , England
Citazione:
A. Zagon, "Activation of cardiac vagal afferents facilitates late vagal inhibition inneurones of the rostral ventrolateral medulla oblongata bilaterally", BRAIN RES, 854(1-2), 2000, pp. 172-177

Abstract

A reduced activity of cardiac vagal afferent fibres is considered as one of the pathophysiological clauses of post-infarction complications [A. Head,Baroreflexes and cardiovascular regulation in hypertension J. Cardiovasc. Pharmacol. 26 (1995) S7-S16]. The mechanism of how a reduction of cardiac vagal activity lends to enhanced sympathetic drive and systemic hypertensionis however not vet clear. Experimental data have shown that the rostral ventrolateral medulla oblongata (RVLM I) plays an important role in tonic blood pressure regulation, the control of sympathetic vasoconstriction and cardiac performance. The aim of the study was to determine whether activation of cardiac vagal afferents contributes to eliciting the long-lasting late inhibition that ae have previously shown to occur in neurones of the RVLM [A. Zagon, K. Ishizuka, I. Rocha, K.M.. Spyer, Late vagal inhibition in neurones of the ventrolateral medulla oblongata in the mt. Neurosci. 92 (1999) 877-888]. The experiments were carried out in terminally anaesthetised and artificially ventilated rats using in vivo intracellular recordings. The data confirmed that late vagal inhibition is elicited by cumulative activationof functionally different vagal afferents, including those that originate from cardiac receptors. It was also demonstrated that activation of cardiacafferents could lead to a significant increase in the duration of this long-lasting late response component. Facilitation of late vagal inhibition was observed in RVLM neurones both ipsi- and contralateral to the stimulated nerve. It is suggested that such facilitation of Late vagal inhibition may be a mechanism of how pulse-synchronous activation of cardiac afferents leads to a tonic modulation of the activity of RVLM neurones. An attenuation of late vagal inhibition during reduced activity of cardiac vagal afferents could lead to enhanced excitability in these neurones which in turn can lend to an increase in medullary sympathetic outflows towards the heart and peripheral blood vessels. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:28:33