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Titolo:
Increased numbers of CCR5(+) interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients
Autore:
Strunk, T; Bubel, S; Mascher, B; Schlenke, P; Kirchner, H; Wandinger, KP;
Indirizzi:
NINDS, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MDUSA 20892 roimmunol Branch, NIH, Bethesda, MD 20892 USA Univ Lubeck, Sch Med, Dept Neurol, D-2400 Lubeck, Germany Univ Lubeck Lubeck Germany D-2400 d, Dept Neurol, D-2400 Lubeck, Germany Univ Lubeck, Sch Med, Inst Immunol & Transfus Med, D-2400 Lubeck, Germany Univ Lubeck Lubeck Germany D-2400 & Transfus Med, D-2400 Lubeck, Germany
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 269 - 273
SICI:
0364-5134(200002)47:2<269:INOCIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXACERBATIONS; EXPRESSION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Wandinger, KP NINDS, Neuroimmunol Branch, NIH, Bldg 10 Room 5B-16,10 Ctr DR MSC 1400, Bethesda, MD 20892 USA NINDS Bldg 10 Room 5B-16,10 Ctr DR MSC 1400 Bethesda MD USA 20892
Citazione:
T. Strunk et al., "Increased numbers of CCR5(+) interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients", ANN NEUROL, 47(2), 2000, pp. 269-273

Abstract

To determine the frequency of in vivo activated T(H)1 lymphocytes; T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthycontrols were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5(+) interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:38:40