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Titolo:
Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
Autore:
Bierut, LJ; Rice, JP; Edenberg, HJ; Goate, A; Foroud, T; Cloninger, CR; Begleiter, H; Conneally, PM; Crowe, RR; Hesselbrock, V; Li, TK; Nurnberger, JI; Porjesz, B; Schuckit, MA; Reich, T;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Indiana Univ, Med Ctr, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA 46204 ed Ctr, Indianapolis, IN 46204 USA SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 h Sci Ctr, Brooklyn, NY 11203 USA Univ Iowa, Coll Med, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Iowa, Coll Med, Iowa City, IA 52242 USA Univ Connecticut, Farmington, CT USA Univ Connecticut Farmington CT USAUniv Connecticut, Farmington, CT USA Univ Calif San Diego, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 iego, San Diego, CA 92103 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 90, anno: 2000,
pagine: 299 - 302
SICI:
0148-7299(20000214)90:4<299:FSOTAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE DISEQUILIBRIUM; DEPENDENCE; RISK; TDT;
Keywords:
smoking; dopamine; DRD2; genetics; family study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bierut, LJ Washington Univ, Sch Med, Dept Psychiat, 4940 Childrens Pl, St Louis, MO 63110 USA Washington Univ 4940 Childrens Pl St Louis MO USA 63110110 USA
Citazione:
L.J. Bierut et al., "Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking", AM J MED G, 90(4), 2000, pp. 299-302

Abstract

A recent study showed an association between the dopamine D2 receptor gene(DRD2) and smoking. The purpose of this study was to determine if the familial transmission of smoking is linked to variation at the DRD2 locus in a genetically informative sample, Subjects were identified in alcohol treatment centers and their relatives were recruited for study. All subjects were interviewed to assess alcohol dependence, smoking habits, and psychiatric disorders. Two polymorphisms within the DRD2 gene were analyzed, including the TaqIA polymorphism. The sample consisted of 138 nuclear families with atleast one offspring with habitual smoking, and analysis was by the transmission disequilibrium test (TDT), which avoids problems due to population stratification. There was no significant difference in the frequency between DRD2 alleles transmitted and not transmitted to habitual smokers, There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 23/09/20 alle ore 11:02:06