Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Function and X chromosome inactivation analysis of B lymphocytes in myelodysplastic syndromes with immunological abnormalities
Autore:
Okada, M; Okamoto, T; Takemoto, Y; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan
Titolo Testata:
ACTA HAEMATOLOGICA
fascicolo: 3, volume: 102, anno: 1999,
pagine: 124 - 130
SICI:
0001-5792(1999)102:3<124:FAXCIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISMS; SYSTEMIC LUPUS-ERYTHEMATOSUS; CLONAL ANALYSIS; INSITU HYBRIDIZATION; LINEAGE INVOLVEMENT; HEMATOPOIETIC-CELLS; GENE; METHYLATION; PATTERNS; THERAPY;
Keywords:
IL-6; IL-10; immunological abnormalities; myelodysplastic syndrome; X chromosome inactivation pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Okamoto, T Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya HyogoJapan 6638501
Citazione:
M. Okada et al., "Function and X chromosome inactivation analysis of B lymphocytes in myelodysplastic syndromes with immunological abnormalities", ACT HAEMAT, 102(3), 1999, pp. 124-130

Abstract

To investigate the pathogenesis of immunological abnormalities (IA) in myelodysplastic syndrome (MDS), we examined B cells for their ability to produce cytokine and their X chromosome inactivation pattern (XCIP). An IA was defined as being positive for at least one autoimmune laboratory test (e.g. antinuclear antibody, rheumatoid factor). Seventy-three MDS patients [65 with refractory anemia (RA), 3 with RA with excess blasts (RAEB), and 5 with RAEB in transformation] were examined; 47 had IA and 26 had no IA. To examine the function of B cells in MDS, the production of interleukin (IL)-6 andIL-10 was measured in cultures of purified B cells with or without stimulators. Both IL-6 and IL-10 production rates in patients with IA were significantly higher than in patients without IA and normal controls. The skewing of XCIP of B cells was analyzed by using the polymerase chain reaction, andthe skewing rate of B cell XCIP was quantitatively assayed by compared to control T lymphocytes. The skewing rate of B cells was higher in patients with IA than in those without IA and normal controls. Therefore, a small population of B cells in patients with IA might be derived from MDS clones, and be associated with the induction of IA. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 20:43:13