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Titolo:
Lectin-binding patterns in normal, hyperplastic and neoplastic endometrium: the prognostic value of concanavalin A
Autore:
Sivridis, E; Giatromanolaki, A; Koukourakis, M; Agnantis, N;
Indirizzi:
Democritus Univ Thrace, Gen Hosp, Dept Pathol, GR-68100 Alexandroupolis, Greece Democritus Univ Thrace Alexandroupolis Greece GR-68100 droupolis, Greece Univ Hosp Iraklion, Dept Radiotherapy & Oncol, Iraklion, Greece Univ Hosp Iraklion Iraklion Greece diotherapy & Oncol, Iraklion, Greece Univ Ioannina, Dept Pathol, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 Pathol, GR-45110 Ioannina, Greece
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 436, anno: 2000,
pagine: 52 - 58
SICI:
0945-6317(200001)436:1<52:LPINHA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOCARCINOMA; CARCINOMA; AGGLUTININ; REACTIVITY; INVASION; MARKERS;
Keywords:
endometrium; endometrial carcinoma; lectins; Con A; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sivridis, E Democritus Univ Thrace, Gen Hosp, Dept Pathol, POB 128, GR-68100 Alexandroupolis, Greece Democritus Univ Thrace POB 128 Alexandroupolis Greece GR-68100
Citazione:
E. Sivridis et al., "Lectin-binding patterns in normal, hyperplastic and neoplastic endometrium: the prognostic value of concanavalin A", VIRCHOWS AR, 436(1), 2000, pp. 52-58

Abstract

Lectins are proteins and glycoproteins of nonimmune origin which bind specifically to carbohydrate residues. agglutinate cells and/or precipitate complex carbohydrates. Lectin-binding patterns in normal, hyperplastic and neoplastic endometria were studied using four biotinylated lectins (Con A, LCA, e-PHA, 1-PHA) and the avidin-biotin-peroxidase technique. Canavalia ensiformis agglutinin (ConA) and Lens culinaris agglutinin (LCA) reacted strongly with the luminal borders and the cytoplasm of epithelial cells but, whilst in normal and benign endometrial tissues the cytoplasmic staining was confined to the apical and the basal aspect of the cells, in endometrial carcinomas and in some atypical hyperplasias lectin binding also occurred in thelateral cytoplasm (Con-A-lat), although in differing proportions of cells. Interestingly, extensive Con-A-lat in the tumour cells was much more frequent in non-endometrioid carcinomas (P<0.05) and was significantly associated with poor histological differentiation (P<0.0001), low oestrogen and progesterone receptor content (P<0.01 and P=0.0001, respectively) and an unfavourable long-term survival (P<0.05). With Phaseolus vulgaris erythroagglutinin (e-PHA) and leucoagglutinin (l-PHA) a linear, rather inconsistent, staining at the level of the basement membranes was observed in the glands: this, also noted with LCA, appeared intact in normal and hyperplastic glands without cytological atypia, and fragmented or absent in malignant glandular structures and in most hyperplastic glands showing cytological atypia. It isconcluded that changes in the distribution of lectin-binding molecules in the endometrial cells are associated with the malignant state, whilst the extent of Con-A-lat reflects the biological behaviour of the tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:17:10