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Titolo:
Paralytic toxins in a ribbon worm Cephalothrix species (Nemertean) adherent to cultured oysters in Hiroshima Bay, Hiroshima Prefecture, Japan
Autore:
Asakawa, M; Toyoshima, T; Shida, Y; Noguchi, T; Miyazawa, K;
Indirizzi:
Hiroshima Univ, Fac Appl Biol Sci, Hiroshima 7398528, Japan Hiroshima Univ Hiroshima Japan 7398528 iol Sci, Hiroshima 7398528, Japan Tokyo Coll Pharm, Tokyo 1920392, Japan Tokyo Coll Pharm Tokyo Japan 1920392 yo Coll Pharm, Tokyo 1920392, Japan Nagasaki Univ, Fac Fisheries, Lab Food Hyg, Nagasaki 8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 b Food Hyg, Nagasaki 8528521, Japan
Titolo Testata:
TOXICON
fascicolo: 6, volume: 38, anno: 2000,
pagine: 763 - 773
SICI:
0041-0101(200006)38:6<763:PTIARW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOSHUBORA CHARONIA-SAULIAE; SHELLFISH POISON; ALEXANDRIUM-TAMARENSE; TRUMPET SHELL; TETRODOTOXIN; TOXIFICATION; ASSOCIATION; GASTROPOD; BIVALVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Asakawa, M Hiroshima Univ, Fac Appl Biol Sci, Hiroshima 7398528, Japan Hiroshima Univ Hiroshima Japan 7398528 roshima 7398528, Japan
Citazione:
M. Asakawa et al., "Paralytic toxins in a ribbon worm Cephalothrix species (Nemertean) adherent to cultured oysters in Hiroshima Bay, Hiroshima Prefecture, Japan", TOXICON, 38(6), 2000, pp. 763-773

Abstract

In 1998, during the surveillance of the toxicity of various marine foulingorganisms in Hiroshima Bay, Hiroshima Prefecture, Japan, specimens of the ribbon worm, "himomushi" Cephalothrix sp. (Nemertean) adherent to the shells of cultured oysters hanging onto floating culture rafts were found to contain toxins which showed strong paralytic action in mice throughout the survey period, February to May. The maximum toxicity (as tetrodotoxin, TTX) was 14,734 MU/g whole body. Attempts were made to identify the paralytic toxins in this worm. The "himomushi" toxin (HMT) was extracted from the worm with 80 methanol acidified with acetic acid and the extract defatted with dichloromethane. The aqueous layer was chromatographed on activated charcoal and the unbound and bound toxic fractions were analyzed by high-performance liquid chromatography and gas chromatography-mass spectrometry. It was rather unexpectedly revealed from these results that HMT was comprised of TTX, 4-epiTTX, anhydroTTX and three unidentified toxins. To our knowledge, this is the first report of the occurrence of toxic organisms, containing a highconcentration of TTX, adherent to cultured bivalves such as oysters. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:31:56