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Titolo:
An integrative approach to neurotoxicology
Autore:
Dorman, DC;
Indirizzi:
Chem Ind Inst Toxicol, Res Triangle Pk, NC 27709 USA Chem Ind Inst Toxicol Res Triangle Pk NC USA 27709 angle Pk, NC 27709 USA
Titolo Testata:
TOXICOLOGIC PATHOLOGY
fascicolo: 1, volume: 28, anno: 2000,
pagine: 37 - 42
SICI:
0192-6233(200001/02)28:1<37:AIATN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-BRAIN-BARRIER; MANGANESE-INTOXICATED MONKEYS; P-GLYCOPROTEIN DEFICIENCY; REPEATED ACQUISITION; MPTP NEUROTOXICITY; TRIMETHYLTIN; RATS; ACRYLAMIDE; MECHANISMS; PARKINSONISM;
Keywords:
neurotoxicology; risk assessment; trimethyltin; acrylamide; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); manganese;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Dorman, DC Chem Ind Inst Toxicol, POB 12137,6 Davis Dr, Res Triangle Pk, NC 27709 USA Chem Ind Inst Toxicol POB 12137,6 Davis Dr Res Triangle Pk NC USA 27709
Citazione:
D.C. Dorman, "An integrative approach to neurotoxicology", TOX PATHOL, 28(1), 2000, pp. 37-42

Abstract

Exposure of human populations to a wide variety of chemicals has generatedconcern about the potential neurotoxicity of new and existing chemicals. Experimental studies conducted in laboratory animals remain critical to the study of neurotoxicity. An integrative approach using pharmacokinetic, neuropathological, neurochemical, electrophysiological, and behavioral methods is needed to determine whether a chemical is neurotoxic. There are a numberof factors that can affect the outcome of a neurotoxicity study, includingthe choice of animal species, dose and dosage regimen, route of administration, and the intrinsic sensitivity of the nervous system to the test chemical. The neurotoxicity of a chemical can vary at different stages of brain development and maturity. Evidence of neurotoxicity may be highly subjective and species specific and can be complicated by the presence of systemic disease. The aim of this paper is to give an overview of these and other factors involved in the assessment of the neurotoxic potential for chemicals. This article discusses the neurotoxicity of several neurotoxicants (eg, acrylamide, trimethyltin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, manganese, and ivermectin), thereby highlighting a multidisciplinary approach to the assessment of chemically induced neurotoxicity in animals. These model chemicals produce a broad range of effects that includes peripheral axonopathy, selective neuronal damage within the nervous system, and impaired neuronal-glial metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/08/20 alle ore 22:29:05