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Titolo:
HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes
Autore:
Undlien, DE; Kockum, I; Ronningen, KS; Lowe, R; Saanjeevi, CB; Graham, J; Lie, BA; Akselsen, HE; Lernmark, A; Thorsby, E;
Indirizzi:
Univ Oslo, Natl Hosp, Inst Immunol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 atl Hosp, Inst Immunol, N-0027 Oslo, Norway Karolinska Inst, Dept Mol Med, Stockholm, Sweden Karolinska Inst Stockholm Sweden Inst, Dept Mol Med, Stockholm, Sweden Natl Inst Publ Hlth, Dept Populat Hlth Sci, Oslo, Norway Natl Inst Publ Hlth Oslo Norway th, Dept Populat Hlth Sci, Oslo, Norway Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Biostat, Seattle, WA USA Univ Washington Seattle WAUSA Washington, Dept Biostat, Seattle, WA USA
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 6, volume: 54, anno: 1999,
pagine: 543 - 551
SICI:
0001-2815(199912)54:6<543:HAIT1D>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II ALLELES; GENETIC-HETEROGENEITY; NORWEGIAN PATIENTS; ISLET-CELL; MELLITUS; SUSCEPTIBILITY; DQ; IDDM; RESISTANCE; CAUCASIANS;
Keywords:
disease susceptibility; genotype; HLA class II antigens; insulin-dependent diabetes mellitus; transmission disequilibrium test (TDT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Undlien, DE Univ Oslo, Natl Hosp, Inst Immunol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 st Immunol, N-0027 Oslo, Norway
Citazione:
D.E. Undlien et al., "HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes", TISSUE ANTI, 54(6), 1999, pp. 543-551

Abstract

Type 1 diabetes is a complex disease where numerous genes are involved in the pathogenesis. Genes that account for approximately 50% of the familial clustering of the disease are located within or in the vicinity of the HLA complex on chromosome 6. Some DRB1, DQA1 and DQB1 genes are known to be involved, in addition to as yet unidentified HLA-linked genes. The DR4-DQ8 andDR3-DQ2 haplotypes are known to confer high risk for developing the disease, particularly when occurring together. Approximately 10% of patients, however,do not carry any of these high-risk HLA class II haplotypes. We have performed genotyping of DRB1, DQA1 and DQB1 alleles in non-DR3-DQ2/non-DR4-DQ8 patients and controls from Sweden and Norway to test if any HLA associations were observed in these patients our results clearly demonstrate several statistically significant differences in the frequency of HLA haplotypes between patients and controls. Case-control analysis including the relativepredispositional effect test, and transmission disequilibrium test (TDT) analysis in Norwegian type 1 diabetes families revealed that the DQA1*03-DQB1*0301, DQA1*0401-DQB1*0402, DQA1*0101-DQB1*0501, DQA1*03-DQB1*0303 and DQA1*0102-DQB1*0604 haplotypes may also confer risk. Our analyses also supported independent risks of certain DRB1 alleles. The study clearly demonstrates that HLA associations in type 1 diabetes extends far beyond the well-known associations with the DR4-DQ8 and DR3-DQ2 haplotypes. Our data suggest that there is a hierarchy of HLA class II haplotypes conferring risk to develop type 1 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:50:58