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Titolo:
Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly
Autore:
de Leeuw, FE; de Groot, JC; Oudkerk, M; Witteman, JCM; Hofman, A; van Gijn, J; Breteler, MMB;
Indirizzi:
Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, Daniel Den Hoed Canc Clin, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Erasmus Univ, Sch Med, Dept Radiol, Daniel Den Hoed Canc Clin, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
STROKE
fascicolo: 2, volume: 31, anno: 2000,
pagine: 425 - 429
SICI:
0039-2499(200002)31:2<425:AAAMAP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR RISK-FACTORS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; YOUNG-ADULTS; ROTTERDAM; POPULATION; PATHOGENESIS;
Keywords:
cerebrovascular disorders; atherosclerosis; leukoaraiosis; magnetic resonance imaging; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Breteler, MMB Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, Daniel Den Hoed Canc Clin, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR ands
Citazione:
F.E. de Leeuw et al., "Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly", STROKE, 31(2), 2000, pp. 425-429

Abstract

Background and Purpose-MRI scans of the brains of elderly people frequently show white matter lesions. Clinically, these lesions are associated with cognitive impairment and dementia. A relation between atherosclerosis and white matter lesions was found in some small cross-sectional studies, However, atherosclerosis is a gradual process that starts early in life. We investigated the longitudinal association between aortic atherosclerosis assessed during midlife and late life and cerebral white matter lesions. Methods-We randomly sampled subjects between 60 and 90 years old from 2 population-based follow-up studies in which subjects had their baseline examinations in 1975 to 1978 (midlife) and in 1990 to 1993 (late life). In 1995 to 1996, subjects underwent 1.5-T MRI scanning; white matter lesions were rated in the deep subcortical and periventricular regions separately, Aorticatherosclerosis was assessed on abdominal radiographs that were obtained from 276 subjects in midlife and 531 subjects in late life. Results-The presence of aortic atherosclerosis during midlife was significantly associated with the presence of periventricular white matter lesions approximate to 20 years later (adjusted relative risk, 2.4; 95% CI, 1.2 to 5.0); the relative risks increased linearly with the severity of aortic atherosclerosis. No association was found between midlife aortic atherosclerosis and subcortical white matter lesions (adjusted relative risk, 1.1; 95% CI, 0.5 to 2.3) or between late-life aortic atherosclerosis and white matterlesions,Conclusions-The pathogenetic process that leads to cerebral periventricular white matter lesions starts already in or before midlife, The critical period for intervention directed at prevention of white matter lesions and its cognitive consequences may be long before these lesions become clinicallydetectable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:14:45