Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Release of neuropeptide Y and hemodynamic changes during surgical removal of human pheochromocytomas
Autore:
Eurin, J; Barthelemy, C; Masson, F; Maistre, G; Soualmia, H; Noe, E; Sarfati, E; Eurin, B; Carayon, A;
Indirizzi:
CHU Pitie Salpetriere, Serv Biochim Med, F-75013 Paris, France CHU Pitie Salpetriere Paris France F-75013 im Med, F-75013 Paris, France Hop St Louis, Serv Chirurg Gen, F-75010 Paris, France Hop St Louis ParisFrance F-75010 erv Chirurg Gen, F-75010 Paris, France Hop St Louis, Serv Anesthesie Reanimat, F-75010 Paris, France Hop St Louis Paris France F-75010 thesie Reanimat, F-75010 Paris, France
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-3, volume: 86, anno: 2000,
pagine: 95 - 102
SICI:
0167-0115(20000129)86:1-3<95:RONYAH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; ATRIAL-NATRIURETIC-PEPTIDE; PLASMA-CONCENTRATIONS; CATECHOLAMINE LEVELS; IMMUNOREACTIVITY; EXPRESSION; TUMORS; ACTIVATION; ELEVATION; BENIGN;
Keywords:
norepineprhine; systemic vascular resistances;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Eurin, J CHU Pitie Salpetriere, Serv Biochim Med, F-75013 Paris, France CHU Pitie Salpetriere Paris France F-75013 -75013 Paris, France
Citazione:
J. Eurin et al., "Release of neuropeptide Y and hemodynamic changes during surgical removal of human pheochromocytomas", REGUL PEPT, 86(1-3), 2000, pp. 95-102

Abstract

This study investigates the release of Neuropeptide Y from eight human pheochromocytomas. Profil immunoreactive Neuropeptide Y (Ir-NPY) levels duringthe management of surgery were compared with these of norepinephrine (NE) while hemodynamics were monitored. Plasma IrNPY and NE levels increased during tumor manipulation and returned to near normal one hour after operation. However, Ir-NPY levels remained high just after tumor resection while NE levels were significantly decreased. At tumor manipulation and just after tumor resection, plasma Ir-NPY levels were correlated with the systemic vascular resistances (SVR) (r = 0.74; P < 0.04 and r = 0.86; P < 0.006 respectively). No correlation was found either between plasma Ir-NPY and NE levels or between plasma NE levels and SVR. The release of Ir-NPY from tumor tissue, studied by a superfusion method, exhibited a significant correlation with the plasma Ir-NPY concentrations at the time of corresponding tumor resection (r = 0.95; P < 0.007). Chromatographic analysis showed that Ir-NPY in plasma and outflow migrate as human NPY(1-36). These results confirmed thatin pheochromocytoma, plasma NPY mainly originates from the tumor and arguefor an important role of NPY in pheochromocytoma hypertension as indicatedby the correlation between the Ir-NPY levels and the SVR. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:20:00