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Titolo:
Transgenic models as tools for studying the regulation of human renin expression
Autore:
Sinn, PL; Sigmund, CD;
Indirizzi:
Univ Iowa, Coll Med, Dept Internal Med, Med Lab 2191, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 d, Med Lab 2191, Iowa City, IA 52242 USA
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-3, volume: 86, anno: 2000,
pagine: 77 - 82
SICI:
0167-0115(20000129)86:1-3<77:TMATFS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ANGIOTENSINOGEN GENES; CELL-SPECIFIC EXPRESSION; MICE; PROMOTER; HYPERTENSION; TISSUE; TRANSCRIPTION; SECRETION; CONSTRUCT; ELEMENTS;
Keywords:
transgenic models; human renin; protein over-production; renin-angiotensin system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sigmund, CD Univ Iowa, Coll Med, Dept Internal Med, Med Lab 2191, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 191, Iowa City, IA 52242 USA
Citazione:
P.L. Sinn e C.D. Sigmund, "Transgenic models as tools for studying the regulation of human renin expression", REGUL PEPT, 86(1-3), 2000, pp. 77-82

Abstract

Transgenic mice and rats have become popular tools to study the regulationof gene expression and the consequences of protein over-production. Over the past decade, numerous transgenic models have been developed to study themechanisms of human renin gene expression and the participation of the renin-angiotensin system in the development of hypertension. Herein we will provide an overview: of what has been learned from the use of transgenic models for studying the human renin gene. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:25:15