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Titolo:
Selective mu and delta, but not kappa, opiate receptor antagonists inhibitthe habituation of novelty-induced hypoalgesia in the rat
Autore:
Spreekmeester, E; Rochford, J;
Indirizzi:
McGill Univ, Dept Psychiat, Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 148, anno: 2000,
pagine: 99 - 105
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-INDUCED ANALGESIA; OPIOID RECEPTORS; MEDIATED ANTINOCICEPTION; HOT-PLATE; NEUROTRANSMITTER RELEASE; BRAIN; NALOXONE; AGONISTS; PAIN; MODULATION;
Keywords:
opiate receptor; antinociception; habituation; novelty; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Rochford, J McGill Univ, Dept Psychiat, Douglas Hosp, Res Ctr, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 Canada
Citazione:
E. Spreekmeester e J. Rochford, "Selective mu and delta, but not kappa, opiate receptor antagonists inhibitthe habituation of novelty-induced hypoalgesia in the rat", PSYCHOPHAR, 148(1), 2000, pp. 99-105

Abstract

Rationale: There is now extensive evidence demonstrating that exposure to novel stimuli induces hypoalgesia and that this effect habituates over repeated exposure to the stimuli. Moreover. it has been shown that administration of the nonselective opiate receptor antagonist naloxone can attenuate the rate of habituation of novelty-induced hypoalgesia. Objectives: The present experiments were conducted to determine the relative influence of different opiate receptor subtypes in the attenuation of the habituation of novelty-induced hypoalgesia. Methods: In experiments 1-3, different groups of male, Wistar rats (275-300 g) were administered vehicle, 0.5, 1.0 or 2.0-nmoldoses of the mu-selective antagonist Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide (CTOP), the delta-receptor selective antagonist naltrindole, or the kappa-selective antagonist norbinaltorphimine (nor-BNI). In experiment 4, animals were administered vehicle, 5, 25 or 75-nmol doses of nor-BNI. All injections were delivered to the right lateral ventricle 30 min prior to exposure to a never hot-plate apparatus (48.5 degrees C), once a day for eight consecutive days. Results: Paw-lick latencies in vehicle-treated animals were long during the initial exposures and declined over repeated tests, suggesting thehabituation of novelty-induced hypoalgesia. The rate of habituation was significantly attenuated by administration of 1.0-nmol and 2.0-nmol doses of CTOP, by a 2.0-nmol dose of naltrindole, but was unaffected by all doses ofnor-BNI. Conclusions: These results support the involvement of the Ct and delta, but not the kappa, opiate receptor subtypes in the habituation of novelty-induced hypoalgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:53:16