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Titolo:
How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
Autore:
Rivest, S; Lacroix, S; Vallieres, L; Nadeau, S; Zhang, J; Laflamme, N;
Indirizzi:
CHU Laval, Mol Endocrinol Lab, Res Ctr, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada Univ Laval, Dept Anat & Physiol, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada
Titolo Testata:
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 1, volume: 223, anno: 2000,
pagine: 22 - 38
SICI:
0037-9727(200001)223:1<22:HTBTTT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING-FACTOR; NF-KAPPA-B; SIGNAL TRANSDUCER GP130; IL-1 RECEPTOR ANTAGONIST; ACTIVATED PROTEIN-KINASE; CD14 GENE-EXPRESSION; PLASMA ADRENOCORTICOTROPIN RESPONSE; CYCLOOXYGENASE-2 MESSENGER-RNA; VASCULAR ENDOTHELIAL-CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Rivest, S CHU Laval, Mol Endocrinol Lab, Res Ctr, 2705 Blvd Laurier, Quebec City, PQG1V 4G2, Canada CHU Laval 2705 Blvd Laurier Quebec City PQ CanadaG1V 4G2 Canada
Citazione:
S. Rivest et al., "How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli", P SOC EXP M, 223(1), 2000, pp. 22-38

Abstract

There are exciting new developments regarding the molecular mechanisms involved in the Influence of circulating proinflammatory molecules within cells of the blood-brain barrier (BBB) during systemic immune challenges. Thesemolecules, when present in the circulation, have the ability to trigger a series of events In cascade, leading to either the mitogen-activated protein (MAP) kinases/nuclear factor kappa B (NF-kappa B) or the janus kinase (JAK)/signal transducer and activator of transcription (STAT) transduction pathways in vascular-associated cells of the central nervous system (CNS). Thebrain blood vessels exhibit both constitutive and induced expression of receptors for different proinflammatory ligands that have the ability to stimulate these signaling molecules. Depending on the challenges and the cytokines involved, the transduction signal(s) solicited in cells of the BBB may orient the neuronal activity in a very specific manner in activating the transcription and production of soluble factors, such as prostaglandins (PGs). It is interesting to note that cytokines as well as systemic localized inflammation stimulate the cells of the BBB In a nonselective manner (i.e., within both large blood vessels and small capillaries across the brain). This nonselectivity raises several questions with regard to the localized neuronal activation induced by different experimental models of inflammation and cytokines. It is possible that the selectivity of the neuronal response Is a consequence of the fine interaction between nonparenchymal synthesis ofsoluble mediators and expression of specific receptors for these ligands, within parenchymal elements of different brain nuclei, This review will present the recent developments on this concept and the mechanisms that take place in cells of the BBB, which lead to the neuronal circuits involved in restoring the body's homeostasis during systemic immunogenic challenges. Theinduction of fever, the hypothalamic-pituitary adrenal (HPA) axis, and other autonomic functions are among the physiological outcomes necessary far the protection of the mammalian organism in the: presence of foreign material.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:49:35