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Titolo:
Simultaneous determination of paroxetine, risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography with coulometric detection
Autore:
Schatz, DS; Saria, A;
Indirizzi:
Univ Innsbruck Hosp, Dept Psychiat, Div Neurochem, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria
Titolo Testata:
PHARMACOLOGY
fascicolo: 1, volume: 60, anno: 2000,
pagine: 51 - 56
SICI:
0031-7012(200001)60:1<51:SDOPRA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE EXTRACTION; ELECTROCHEMICAL DETECTION; SERUM;
Keywords:
paroxetine; risperidone; 9-hydroxyrisperidone; high-performance liquid chromatography electrochemical detection; coulometric detection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Saria, A Univ Innsbruck Hosp, Dept Psychiat, Div Neurochem, Anichstr 35, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Anichstr 35 Innsbruck AustriaA-6020 Austria
Citazione:
D.S. Schatz e A. Saria, "Simultaneous determination of paroxetine, risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography with coulometric detection", PHARMACOL, 60(1), 2000, pp. 51-56

Abstract

A method for the simultaneous determination of paroxetine, risperidone andits main metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multistep solid-phase liquid extraction with aninternal standard. The drugs were separated on a cyano column followed by coulometric detection. This method described here has sufficient sensitivity to quantitate paroxetine accurately in the range 5-500 ng/ ml with a lower limit of detection of 1 ng/ml and risperidone and its main metabolite 9-hydroxyrisperidone in the range 2-100 ng/ml with a lower limit of detection of 1 ng/ml when 1 ml of plasma was used for the analysis. The precision, accuracy and specificity have been proven, and show that the method is reliable for clinical studies and routine drug monitoring. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:58:59