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Titolo:
Autoradiographic evidence of delta-opioid receptor downregulation after prenatal stress in offspring rat brain
Autore:
Sanchez, MD; Milanes, MV; Pazos, A; Diaz, A; Laorden, ML;
Indirizzi:
Univ Murcia, Sch Med, Dept Physiol & Pharmacol, Murcia, Spain Univ MurciaMurcia Spain h Med, Dept Physiol & Pharmacol, Murcia, Spain Unic Sch Med, Dept Pharmacol, Santander, Spain Unic Sch Med Santander Spain Sch Med, Dept Pharmacol, Santander, Spain
Titolo Testata:
PHARMACOLOGY
fascicolo: 1, volume: 60, anno: 2000,
pagine: 13 - 18
SICI:
0031-7012(200001)60:1<13:AEODRD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ENDORPHIN; OPIATE RECEPTORS; GENE-EXPRESSION; DOWN-REGULATION; BINDING-SITES; MOUSE-BRAIN; MU; ENKEPHALIN; ONTOGENY; KAPPA;
Keywords:
delta-opioid receptors; prenatal stress; offspring; downregulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Laorden, ML Fac Med, Dept Farmacol, Campus Espinardo, E-30100 Murcia, Spain Fac Med Campus Espinardo Murcia Spain E-30100 0 Murcia, Spain
Citazione:
M.D. Sanchez et al., "Autoradiographic evidence of delta-opioid receptor downregulation after prenatal stress in offspring rat brain", PHARMACOL, 60(1), 2000, pp. 13-18

Abstract

In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on offsprings (postnatal day 10) from female rats stressed in different periods of gestation and controls, Group 1 was subjected to restraint stress from day 2 to 6; group 2, from day 7 to 11; group 3, from day 12 to 16; group 4 from day 2 to 16, Group 2 showed decreases in delta-opioid receptor density in different hypothalamic regions. The decrease in delta-opioid receptor density was less marked in groups 1 and 3 whereas there was no modification in group 4, Presentdata suggest that the prenatal stress induces a downregulation of delta-receptors in different hypothalamic regions. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:42:21