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Titolo:
Lavage administration of dilute recombinant surfactant in acute lung injury in piglets
Autore:
Meister, JC; Balaraman, V; Ku, T; DeSilva, A; Sood, S; Uyehara, CFT; Person, DA; Easa, D;
Indirizzi:
Kapiolani Med Ctr Women & Children, Clin Res Ctr, Honolulu, HI 96826 USA Kapiolani Med Ctr Women & Children Honolulu HI USA 96826 lu, HI 96826 USA Univ Hawaii, John A Burns Sch Med, Dept Pediat, Honolulu, HI 96826 USA Univ Hawaii Honolulu HI USA 96826 ed, Dept Pediat, Honolulu, HI 96826 USA Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96850 USA Tripler Army Med Ctr Honolulu HI USA 96850 Invest, Honolulu, HI 96850 USA
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 2, volume: 47, anno: 2000,
pagine: 240 - 245
SICI:
0031-3998(200002)47:2<240:LAODRS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; PREMATURE LAMBS; AEROSOLIZED SURFACTANT; EXOGENOUS SURFACTANT; PRETERM LAMBS; REPLACEMENT; RABBITS; SEPSIS; VOLUME; ARDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Easa, D Kapiolani Med Ctr Women & Children, Clin Res Ctr, 1319 Punahou St,Honolulu, HI 96826 USA Kapiolani Med Ctr Women & Children 1319 Punahou St Honolulu HI USA 96826
Citazione:
J.C. Meister et al., "Lavage administration of dilute recombinant surfactant in acute lung injury in piglets", PEDIAT RES, 47(2), 2000, pp. 240-245

Abstract

In an acute lung injury model, we previously observed reversal of pulmonary dysfunction with natural surfactant administered by lavage (dose = 18 mg/kg phospholipid). The present study questioned whether a lower dose of phospholipid would be effective if a recombinant preparation rather than natural surfactant were used. Acute lung injury was induced by repeated saline lung lavage in ventilated, sedated, and paralyzed piglets. Three concentrations of recombinant surfactant were studied (low phospholipid, 1 mg/mL; medium phospholipid, 4 mg/mL; high phospholipid, 13.5 mg/mL). Control piglets received no surfactant. Thirty-five milliliters per Kilogram of surfactant was administered by gravity, followed by passive drainage of excess fluid. All treatment groups retained similar volumes (4.7 +/- 0.3 mL/kg), corresponding to phospholipid doses of 4 +/- 0.4, 22 +/- 3, and 67 +/- 4 mg/kg in low, medium, and high-dose groups, respectively. Treatment groups showed significant improvement in Pao(2) compared with controls. Other parameters different from controls were found in only the medium and high-dose groups. All surfactant-treated groups showed improvement over time in Pao(2), Paco(2), lung resistance mean airway pressure, functional residual capacity, and dynamic compliance These data support the statement that whereas there is a dose response to exogenous surfactant, the effective dose of recombinant surfactant in acute lung injury may be as low as 4 mg/kg phospholipid when administered by lavage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:44:49