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Titolo:
Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas
Autore:
Yang, YQ; Sanchez, D; Figarella, C; Lowe, ME;
Indirizzi:
Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Pharmacol, St Louis, MO 63110 USA Fac Med, Grp Rech Glandes Exocrines, F-13005 Marseille, France Fac Med Marseille France F-13005 es Exocrines, F-13005 Marseille, France
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 2, volume: 47, anno: 2000,
pagine: 184 - 188
SICI:
0031-3998(200002)47:2<184:DEOPLA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL GENE-EXPRESSION; HUMAN EXOCRINE PANCREAS; HUMAN FETAL PANCREAS; SECRETORY PROTEINS; GESTATIONAL-AGE; DUODENAL JUICE; MESSENGER-RNA; COLIPASE; CONSERVATION; ADAPTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lowe, ME Washington Univ, Sch Med, St Louis Childrens Hosp, Dept Pediat, 1Childrens Pl, St Louis, MO 63110 USA Washington Univ 1 Childrens Pl St Louis MO USA 63110 MO 63110 USA
Citazione:
Y.Q. Yang et al., "Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas", PEDIAT RES, 47(2), 2000, pp. 184-188

Abstract

The lipase gene family contains a large number of members. Among the most closely related are pancreatic triglyceride lipase (PTL) and two pancreaticlipase-related proteins (PLRP1 and PLRP2). Previous studies in rodents demonstrated divergent temporal expression of the genes encoding these proteins. PLRP1 and PLRP2 were expressed in fetal pancreas, whereas PTL was not expressed until pups were several weeks old. To determine whether the human pancreas has a similar expression pattern for these genes, we determined thelevels of each mRNA in fetal pancreas at various ages. A reverse transcriptase-PCR method was developed and used to quantify the mRNA levels for the three species normalized to the mRNA encoding cyclophillin. The mRNA encoding PLRP1 and PLRP2 was present by 16 wk in the fetal pancreas. In contrast,the mRNA encoding PTL was not present in the fetal pancreas. This pattern of expression suggests that the genes encoding theses proteins have different regulatory elements controlling temporal expression and provides anotherexample of nonparallel expression of genes encoding pancreatic exocrine proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:42:35