Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies
Autore:
Phipps, MG; Hogan, JW; Peipert, JF; Lambert-Messerlian, GM; Canick, JA; Seifer, DB;
Indirizzi:
Univ Michigan Hlth Syst, Robert Wood Johnson Clin Scholars Program, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 m, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 l, Ann Arbor, MI 48109 USA Brown Univ, Ctr Stat Sci, Dept Community Hlth, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 mmunity Hlth, Providence, RI 02912 USA Women & Infants Hosp Rhode Isl, Dept Obstet & Gynecol, Providence, RI 02908 USA Women & Infants Hosp Rhode Isl Providence RI USA 02908 ence, RI 02908 USA Women & Infants Hosp Rhode Isl, Dept Pathol & Lab Med, Providence, RI 02908 USA Women & Infants Hosp Rhode Isl Providence RI USA 02908 ence, RI 02908 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Obstet & Gynecol, New Brunswick, NJ USA Univ Med & Dent New Jersey New Brunswick NJ USA l, New Brunswick, NJ USA
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 2, volume: 95, anno: 2000,
pagine: 227 - 231
SICI:
0029-7844(200002)95:2<227:PIAHMM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; SINGLE SERUM PROGESTERONE; ECTOPIC PREGNANCY; SPECIFICITY; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Phipps, MG Univ Michigan Hlth Syst, Robert Wood Johnson Clin Scholars Program, 6312 Med Sci Bldg 1,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst 6312 Med Sci Bldg 1,1150 W Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
M.G. Phipps et al., "Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies", OBSTET GYN, 95(2), 2000, pp. 227-231

Abstract

Objective: To determine whether a combination of serum and urine biomarkers drawn from symptomatic pregnant women will help early differentiation of viable from nonviable pregnancies. Methods: We conducted a prospective cohort study of 220 women who presented in the first trimester of pregnancy with complaints of pain, cramping, bleeding, or spotting. Serum samples for progesterone, inhibin A, and hCG, and urine beta-core hCG, were collected at presentation. To evaluate whether those biomarkers could predict viable and nonviable outcomes in pregnancy, we used likelihood ratios to compare operating characteristics of single and multiple biomarker strategies. Results: Of 220 Pregnancies studied, 98 were viable and 122 nonviable. Among single biomarkers, progesterone alone appears to have the greatest utility (area under the receiver operator characteristic curve = 0.923). Among dual-biomarker strategies, progesterone plus hCG and progesterone plus inhibin A improved specificity but not sensitivity. At 95% sensitivity, the combination of progesterone and hCG improved specificity from 0.29 to 0.66 (improvement 0.37 [95% confidence interval 0.23, 0.52]). A triple-biomarker combination did not show substantial improvement over the dual-biomarker strategy. Also, combinations that used urine beta-core hCG did not improve diagnostic accuracy. Conclusion: Serum progesterone appeared to be the single most specific biomarker for distinguishing viable from nonviable pregnancies. When a dual-biomarker strategy was applied, combining serum progesterone with hCG, specificity improved significantly, which suggests that a multiple biomarker strategy might help distinguish viable from nonviable pregnancies in early gestation. (C) 2000 by The American College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:31:00