Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence that hi-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice
Autore:
Sakurada, T; Sakurada, S; Katsuyama, S; Hayashi, T; Sakurada, C; Tan-No, K; Johansson, H; Sandin, J; Terenius, L;
Indirizzi:
Daiichi Coll Pharmaceut Sci, Dept Biochem, Minami Ku, Fukuoka 8158511, Japan Daiichi Coll Pharmaceut Sci Fukuoka Japan 8158511 Fukuoka 8158511, Japan Tohoku Pharmaceut Univ, Dept Physiol & Anat, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan Tohoku Pharmaceut Univ, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan Karolinska Inst, Dept Clin Neurosci, Expt Alcohol & Drug Addict Res Stn, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Stn, S-17176 Stockholm, Sweden
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 279, anno: 2000,
pagine: 61 - 64
SICI:
0304-3940(20000121)279:1<61:ETHFON>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE FAMILY; SUBSTANCE-P; ORPHANIN FQ/NOCICEPTIN; FQ; ENDOPEPTIDASE-24.15; AMINOPEPTIDASE; CLONING; BINDING; MEMBER; P(1-7);
Keywords:
nociceptin; nociceptin N-terminal fragments; irritant; spinal cord; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sakurada, T Daiichi Coll Pharmaceut Sci, Dept Biochem, Minami Ku, 22-1 Tamagawa Cho, Fukuoka 8158511, Japan Daiichi Coll Pharmaceut Sci 22-1 TamagawaCho Fukuoka Japan 8158511
Citazione:
T. Sakurada et al., "Evidence that hi-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice", NEUROSCI L, 279(1), 2000, pp. 61-64

Abstract

The intrathecal (i.t.) injection of 3.0 fmol nociceptin (orphanin FQ) elicited scratching, biting and licking responses in mice. N-terminal fragmentsof nociceptin, nociceptin (1-7), nociceptin (1-9) and nociceptin (1-13), induced no characteristic behavioral response. When these N-terminal fragments of nociceptin were injected simultaneously with nociceptin, the behavioral response induced by nociceptin was reduced dose-dependently. Nociceptin (1-13) was much more potent than nociceptin (1-7) and nociceptin (1-9) and antagonized nociceptin-induced response at equimolar doses. No significant effects of the N-terminal fragments were observed against the scratching, biting and licking response elicited by i.t. administration of substance P or N-methyl-D-aspartate These results suggest that N-terminal fragments formed endogenously in the spinal cord may have an antagonistic effect on nociceptin-induced behavioral responses. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:28:44