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Titolo:
Gender and age-related variation in adenylyl cyclase activity in the humanprefrontal cortex, hippocampus and dorsal raphe nuclei
Autore:
Palego, L; Giromella, A; Mazzoni, MR; Marazziti, D; Naccarato, AG; Giannaccini, G; Cassano, GB; Lucacchini, A;
Indirizzi:
Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 urobiol Farmacol & Bio, I-56100 Pisa, Italy Univ Pisa, Dipartimento Oncol, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 sa, Dipartimento Oncol, I-56100 Pisa, Italy
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 279, anno: 2000,
pagine: 53 - 56
SICI:
0304-3940(20000121)279:1<53:GAAVIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORSKOLIN; ACTIVATION; DISEASE; BRAIN; ASSAY;
Keywords:
adenylyl cyclase activity; prefrontal cortex; hippocampus; raphe nuclei; human brain post-mortem; gender; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Palego, L Univ Pisa, Dipartimento Psichiatria Neurobiol Farmacol & Bio, Via Bonanno 6, I-56100 Pisa, Italy Univ Pisa Via Bonanno 6 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
L. Palego et al., "Gender and age-related variation in adenylyl cyclase activity in the humanprefrontal cortex, hippocampus and dorsal raphe nuclei", NEUROSCI L, 279(1), 2000, pp. 53-56

Abstract

The influence of gender and age on adenylyl cyclase activity was investigated, through a Dowex-alumina double step chromatographic procedure, in the prefrontal cortex, hippocampus and dorsal raphe nuclei obtained from autopsy cadavers. Results showed that forskolin-stimulated enzyme activity in raphe nuclei was greater in men than in women; a region-dependent rank order of basal, forskolin-induced adenylyl cyclase activity and percentage forskolin-stimulation was observed in women only. Lastly, basal values correlated positively with forskolin-stimulated adenylyl cyclase activity in all areasexcept the prefrontal cortex of the male subjects. Positive significant correlations were also found between both forskolin-stimulated enzyme activity and percentage forskolin stimulation and aging in the prefrontal cortex. Overall, the findings suggest that sex and/or age-related differences in brain adenylyl cyclase vary from one cerebral region to the other. (C) 2000 Published by Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:57:25