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Titolo:
Denervation and NKI receptor block modulate stimulated CGRP and PGE(2) release from rat skin
Autore:
Sauer, SK; Averbeck, B; Reeh, PW;
Indirizzi:
Univ Erlangen, Dept Physiol & Expt Pathophysiol, D-91054 Erlangen, GermanyUniv Erlangen Erlangen Germany D-91054 hysiol, D-91054 Erlangen, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 11, anno: 2000,
pagine: 283 - 286
SICI:
0959-4965(20000207)11:2<283:DANRBM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SUBSTANCE-P; TACHYKININ NK1; SPINAL-CORD; IN-VITRO; BRADYKININ; SYMPATHECTOMY; HYPERALGESIA; NOCICEPTOR; NEURONS;
Keywords:
bradykinin; inflammation; neurokinin I receptor; neuropeptides; nociception; SR 140333;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sauer, SK Univ Erlangen, Dept Physiol & Expt Pathophysiol, Univ Str 17, D-91054 Erlangen, Germany Univ Erlangen Univ Str 17 Erlangen Germany D-91054gen, Germany
Citazione:
S.K. Sauer et al., "Denervation and NKI receptor block modulate stimulated CGRP and PGE(2) release from rat skin", NEUROREPORT, 11(2), 2000, pp. 283-286

Abstract

We investigated the possible neurogenic origin of prostaglandin E-2 (PGE(2)) in the rat skin, in vitro. The hairy skin of one hindpaw was denervated and one week later the dorsal hindpaws were skinned to study the release ofcalcitonin gene-related peptide (CGRP) and PGE(2) using the EIA technique. Stimulation with bradykinin (BK) caused a significant release of CGRP (1.4-fold increase) and PGE(2) (3-fold) which was massively augmented under neurokinin 1 (NK1) receptor antagonist treatment (CGRP: 4-fold, PGE(2): 5-fold). In denervated skin the BK-evoked CGRP release was lost whereas the PGE(2) release was unchanged. Thus, neither nerve endings nor neuropeptides contribute essentially to BK-induced PGE(2) release in the skin. However, excessive neuropeptide levels. as under NK1 blockade facilitate PGE(2) formation, which may play a role in sustained inflammation. NeuroReport 11:283-286 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:38:05