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Titolo:
Effect of three diaryl tellurides, and an organoselenium compound in trouterythrocytes exposed to oxidative stress in vitro
Autore:
Tiano, L; Fedeli, D; Santroni, AM; Villarini, M; Engman, L; Falcioni, G;
Indirizzi:
Univ Camerino, Dipartimento Biol Mol Cellulare & Anim, I-62032 Camerino, MC, Italy Univ Camerino Camerino MC Italy I-62032 Anim, I-62032 Camerino, MC, Italy Univ Perugia, Dipartimento Igiene, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 imento Igiene, I-06100 Perugia, Italy Uppsala Univ, Inst Chem, Dept Organ Chem, Uppsala, Sweden Uppsala Univ Uppsala Sweden Inst Chem, Dept Organ Chem, Uppsala, Sweden
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 2, volume: 464, anno: 2000,
pagine: 269 - 277
SICI:
1383-5718(20000124)464:2<269:EOTDTA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXIDASE-LIKE ACTIVITY; GLUTATHIONE-PEROXIDASE; ORGANOTELLURIUM COMPOUNDS; LIPID-PEROXIDATION; NITROXIDE RADICALS; BLOOD-CELLS; DNA-DAMAGE; EBSELEN; HEMOGLOBIN; INACTIVATION;
Keywords:
trout erythrocytes; oxidative stress; diaryl tellurides; comet assay; DNA; hemolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tiano, L Univ Camerino, Dipartimento Biol Mol Cellulare & Anim, Via Camerini 2, I-62032 Camerino, MC, Italy Univ Camerino Via Camerini 2 Camerino MC Italy I-62032 MC, Italy
Citazione:
L. Tiano et al., "Effect of three diaryl tellurides, and an organoselenium compound in trouterythrocytes exposed to oxidative stress in vitro", MUT RES-GTE, 464(2), 2000, pp. 269-277

Abstract

Previous literature reports have demonstrated that nucleated trout erythrocytes in conditions of oxidative stress are subjected to DNA and membrane damage, and inactivation of glutathione peroxidase. The present study was undertaken to evaluate the ability of three diaryl tellurides and the organoselenium compound ebselen to protect trout (Salmo irideus) erythrocytes against oxidative stress, induced thermally and by a variation of pH. The antioxidant ability of these molecules was evaluated through chemiluminescence. Impairment of DNA was assessed using the comet assay, a rapid and sensitivesingle cell gel electrophoresis technique, used to detect primary DNA damage in individual cells. At low concentrations (< 10 mu M), all the compounds used presented a protective effect on DNA damage without altering the hemolysis rate. In higher concentrations, they accelerated the hemolysis rate and two of the diaryl tellurides were strongly genotoxic. (C) 2000 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:57:46