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Titolo:
Fast network oscillations in the newborn rat hippocampus in vitro
Autore:
Palva, JM; Lamsa, K; Lauri, SE; Rauvala, H; Kaila, K; Taira, T;
Indirizzi:
Univ Helsinki, Dept Biosci, Div Anim Physiol, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Helsinki, Inst Biotechnol, Mol Neurobiol Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 20, anno: 2000,
pagine: 1170 - 1178
SICI:
0270-6474(20000201)20:3<1170:FNOITN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT VISUAL-CORTEX; FREQUENCY OSCILLATIONS; NEONATAL HIPPOCAMPUS; SYNAPTIC PLASTICITY; PYRAMIDAL NEURONS; GRANULE CELLS; DENTATE GYRUS; IN-VITRO; SYNCHRONIZATION; MECHANISMS;
Keywords:
network oscillations; synchronization; neonate; coincidence detection; GABA(A); inhibition; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Taira, T Univ Helsinki, Dept Biosci, Div Anim Physiol, POB 17, FIN-00014 Helsinki, Finland Univ Helsinki POB 17 Helsinki Finland FIN-00014 elsinki, Finland
Citazione:
J.M. Palva et al., "Fast network oscillations in the newborn rat hippocampus in vitro", J NEUROSC, 20(3), 2000, pp. 1170-1178

Abstract

Spontaneous neural activity is crucial for the formation of the intricate patterns of cortical connectivity during development. In particular, temporal correlations in presynaptic and postsynaptic activity have been hypothesized to be a critical determinant in the selection of neurons that are to become wired together. To date, however, temporally correlated activity in the neonatal brain has been believed to take place with a precision of tens of milliseconds to seconds. Here we describe a novel type of a fast network oscillation associated with millisecond synchronization of pyramidal cell firing in newborn rat hippocampus in vitro. Individual pyramidal neurons fired mainly at lower gamma frequencies (20-40 Hz) but were synchronized into a high-frequency (100-400 Hz) population oscillation that was reflected in field potential spikes andintracellular AMPA-kainate receptor-mediated currents. The high-frequency population oscillation was patterned by a gamma-frequency modulatory oscillation. The gamma modulation was imposed by GABAergic currents, which exerted an inhibitory action on pyramidal neurons. Patterned activity based on GABAergic inhibition and glutamatergic excitation thus occurs already in newborn hippocampus. The network oscillations described here may be a mechanismfor selective coincidence detection with a millisecond range temporal precision to shape the patterns of connectivity within the emerging hippocampalsynaptic circuitry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:22:39