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Titolo:
Metabotropic glutamate receptors trigger homosynaptic protein synthesis toprolong long-term potentiation
Autore:
Raymond, CR; Thompson, VL; Tate, WP; Abraham, WC;
Indirizzi:
Univ Otago, Dept Psychol, Dunedin, New Zealand Univ Otago Dunedin New Zealand tago, Dept Psychol, Dunedin, New Zealand Univ Otago, Dept Biochem, Dunedin, New Zealand Univ Otago Dunedin New Zealand tago, Dept Biochem, Dunedin, New Zealand Univ Otago, Neurosci Res Ctr, Dunedin, New Zealand Univ Otago Dunedin New Zealand , Neurosci Res Ctr, Dunedin, New Zealand
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 20, anno: 2000,
pagine: 969 - 976
SICI:
0270-6474(20000201)20:3<969:MGRTHP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT LATE-PHASE; HIPPOCAMPAL-NEURONS; DENTATE GYRUS; MESSENGER-RNA; SYNAPTIC PLASTICITY; DENDRITIC SPINES; RAT HIPPOCAMPUS; IN-VIVO; INDUCTION; LTP;
Keywords:
LTP; mGluRs; metaplasticity; protein synthesis; synaptic plasticity; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Abraham, WC Univ Otago, Dept Psychol, Box 56, Dunedin, New Zealand Univ Otago Box 56 Dunedin New Zealand , Dunedin, New Zealand
Citazione:
C.R. Raymond et al., "Metabotropic glutamate receptors trigger homosynaptic protein synthesis toprolong long-term potentiation", J NEUROSC, 20(3), 2000, pp. 969-976

Abstract

We investigated the mechanisms by which previous "priming" activation of group I metabotropic glutamate receptors (mGluRs) facilitates the persistence of long-term potentiation (LTP) in area CA1 of rat hippocampal slices. Priming of LTP was elicited by either pharmacological or synaptic activation of mGluRs before a weak tetanic stimulus that normally produced only a rapidly decaying phase of LTP that did not involve protein synthesis or mGluRs. Pharmacological priming of LTP persistence by a selective group I mGluR agonist was blocked by an inhibitor of group I mGluRs and by inhibitors of translation, but not by a transcriptional inhibitor. The same mGluR agonist increased S-35-methionine incorporation into slice proteins. LTP could also be facilitated using a synaptic stimulation priming protocol, and this effect was similarly blocked by group I mGluR and protein synthesis inhibitors. Furthermore, using a two-pathway protocol, the synaptic priming of LTP wasfound to be input-specific. To test for the contribution of group I mGluRsand protein synthesis to LTP in nonprimed slices, a longer duration control tetanization protocol was used to elicit a more slowly decaying form of LTP than did the weak tetanus used in the previous experiments. The persistence of the LTP induced by this stronger tetanus was dependent on mGluR activation and protein synthesis but not on transcription. Together, these results suggest that mGluRs couple to nearby protein synthesis machinery to homosynaptically regulate an intermediate phase of LTP dependent on new proteins made from pre-existing mRNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:36:11